The peptidergic neural control of the feline pylorus.

Chirurgisches Forum fur experimentelle und klinische Forschung Pub Date : 1980-01-01 DOI:10.1007/978-3-642-67617-8_47

R Edin, J Lundberg, A Dahlström, T Hökfelt, L Terenius, H Ahlman

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引用次数: 7

Abstract

By immunohistochemistry the three neuropeptides enkephalin, substance P, and VIP were all localized to numerous nerve fibers in the smooth muscle layer and the myenteric plexus of the feline pylorus. The motor activity of the pylorus was studied by recording changes in the volume flow of body-warm saline through the sphincter at constant perfusion pressure in anesthetized cats. Efferent electric stimulation of the cervical vagi (8 V; 5 ms; 8 Hz) elicited a noncholinergic, nonadrenergic pyloric contraction, which was blocked by infusion of the opiate receptor antagonist naloxone. The peptides were injected into a regional gastric artery to the pylorus antrum. Enkephalin and substance P in micronanomolar doses resulted in a prompt contraction of 3 - 5 min duration. Equimolar doses of naloxone blocked the enkephalin-induced contraction, and atropine blocked the SP contraction. On the other hand, VIP caused a prompt dilatation, which could not be blocked in this study. Altogether the findings suggest a peptidergic motor control of the feline pylorus using several transmission mechanisms.

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猫幽门的肽能神经控制。

免疫组化结果显示，脑啡肽、P物质和VIP三种神经肽均分布于猫幽门肌平滑肌层和肌肠丛的众多神经纤维中。通过记录麻醉猫在恒定灌注压力下体温生理盐水通过括约肌的容积流量变化，研究了猫幽门的运动活动。颈迷走神经的传出电刺激(8v);5女士;8 Hz)引起非胆碱性、非肾上腺素性幽门收缩，可通过输注阿片受体拮抗剂纳洛酮阻断。将肽注射到通往幽门窦的胃区域动脉中。微异常剂量的脑啡肽和P物质导致持续3 - 5分钟的迅速收缩。等摩尔剂量纳洛酮阻断脑啡肽诱导的收缩，阿托品阻断SP收缩。另一方面，VIP引起迅速扩张，在本研究中无法阻断。总之，研究结果表明，猫幽门的肽能马达控制使用几种传递机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Chirurgisches Forum fur experimentelle und klinische Forschung

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