Serum proteins in processes associated with an increase in the monoclonal and polyclonal immunoglobulin levels.

L Jakab, S Fekete, K Cseh, S Benedek
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Abstract

The sera of patients with IgG-myeloma, IgM-macroglobulinaemia and with processes accompanied by high polyclonal Ig-levels were measured by radial immunodiffusion for immunoglobulins, coeruloplasmin, alpha-2-macroglobulin, C3-component, transferrin, alpha-1-antitrypsin, alpha-2-haptoglobin and haemopexin. In the presence of typical changes in the immunoglobulin concentrations, elevation of alpha-2-macroglobulin was found only if polyclonal Ig was increased. The concentration of the C3 component was reduced only in IgM macroglobulinaemia, that of transferrin only in IgG-myeloma, that of alpha-2-haptoglobin only in IgM-macroglobulinaemia and in case of increased polyclonal Ig.

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与单克隆和多克隆免疫球蛋白水平升高相关过程中的血清蛋白。
采用放射免疫扩散法检测igg -骨髓瘤、igm -巨球蛋白血症及伴有高多克隆igg水平的患者血清中免疫球蛋白、蓝蛋白、α -2-巨球蛋白、c3组分、转铁蛋白、α -1-抗胰蛋白酶、α -2-血红蛋白和血凝素的含量。在免疫球蛋白浓度存在典型变化的情况下,只有当多克隆Ig增加时才发现α -2巨球蛋白升高。C3成分浓度仅在IgM大球蛋白血症中降低,仅在igg -骨髓瘤中降低,仅在IgM-大球蛋白血症中降低α -2-触珠蛋白浓度,以及在多克隆Ig升高的情况下降低。
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