{"title":"[Presence of 2 different epitopes on the human beta 2-microglobulin defined by monoclonal antibodies].","authors":"D Crevat, J Kalil, F Rosa, M Fellous","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Two monoclonal antibodies recognizing monomorphic determinants on class I antigens of MHC were characterized. They were shown to recognize beta 2m by cytotoxicity inhibition studies. The epitopes recognized were different, as assayed by cross-inhibition and phylogenetical studies. One antibody recognized free as well as HLA-associated beta 2m. The other reacted with a conformational epitope which was well conserved during evolution.</p>","PeriodicalId":75508,"journal":{"name":"Annales d'immunologie","volume":"134C 1","pages":"31-41"},"PeriodicalIF":0.0000,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annales d'immunologie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Two monoclonal antibodies recognizing monomorphic determinants on class I antigens of MHC were characterized. They were shown to recognize beta 2m by cytotoxicity inhibition studies. The epitopes recognized were different, as assayed by cross-inhibition and phylogenetical studies. One antibody recognized free as well as HLA-associated beta 2m. The other reacted with a conformational epitope which was well conserved during evolution.
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