{"title":"The swift increase in alcohol metabolism.","authors":"T Yuki, R G Thurman","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Gastric intubation of female Sprague-Dawley rats with 5 g of ethanol/kg body wt doubled oxygen and ethanol uptake by the isolated perfused rat liver after only 2-5 h of treatment (Swift Increase in Alcohol Metabolism). Diminished ATP generation via glycolysis accounts for a portion of the increased oxygen uptake. These data indicate that at least part of the stimulated oxygen uptake after treatment with ethanol is a result of lower rates of glycolytic ATP generation resulting from hormone action. The ADP not phosphorylated in the cytocol enters the mitochondrion where it stimulates oxygen uptake.</p>","PeriodicalId":75769,"journal":{"name":"Currents in alcoholism","volume":"8 ","pages":"445-52"},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Currents in alcoholism","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Gastric intubation of female Sprague-Dawley rats with 5 g of ethanol/kg body wt doubled oxygen and ethanol uptake by the isolated perfused rat liver after only 2-5 h of treatment (Swift Increase in Alcohol Metabolism). Diminished ATP generation via glycolysis accounts for a portion of the increased oxygen uptake. These data indicate that at least part of the stimulated oxygen uptake after treatment with ethanol is a result of lower rates of glycolytic ATP generation resulting from hormone action. The ADP not phosphorylated in the cytocol enters the mitochondrion where it stimulates oxygen uptake.
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