[The usefulness of dexamethasonephosphate in the conservative treatment of lumbar pain--a double-blind study (author's transl)].

B Hofferberth, M Gottschaldt, H Grass, K Büttner
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引用次数: 4

Abstract

Analgesic drugs, physiotherapy and corticosteroids are concurrently used in the conservative treatment of lumbar pain. In 100 patients a double-blind study with dexamethasonephosphate versus placebo was performed. Lumbar pain and no findings with myelography were the basic requirements for inclusion into the study. There was no significant difference between the treatment group and the placebo group concerning the clinical investigation before and after treatment. The positive effect of dexamethasonephosphate, which was seen in a pilot study, was not confirmed in the double-blind study. Because corticosteroids are also psychotropic drugs there is a mild antidepressive effect. Considering the fact that cortisone has no effect on the symptoms of lumbar pain, it should not be used furthermore in the conservative treatment of lumbar pain.

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[地塞米松磷酸酯在腰椎疼痛保守治疗中的有效性——一项双盲研究[作者摘要]。
止痛药物、物理治疗和皮质类固醇同时用于腰椎痛的保守治疗。在100例患者中进行了地塞米松磷酸酯与安慰剂的双盲研究。腰椎疼痛和脊髓造影无发现是纳入研究的基本要求。治疗组与安慰剂组治疗前后的临床调查无显著差异。地塞米松磷酸酯的积极作用在一项初步研究中发现,但在双盲研究中未得到证实。因为皮质类固醇也是精神药物,所以有轻微的抗抑郁作用。考虑到可的松对腰痛的症状没有影响,因此不应进一步用于腰痛的保守治疗。
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