An epidemiological study of Hirschsprung's disease.

IF 6.4 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH International journal of epidemiology Pub Date : 1984-12-01 DOI:10.1093/ije/13.4.479
E L Goldberg
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引用次数: 105

Abstract

All newly diagnosed cases of Hirschsprung's Disease among children born in Baltimore City and County, Maryland and diagnosed within the Baltimore Standard Metropolitan Area during 1969 through 1977 were identified. Using hospital records and death certificates, 33 cases were ascertained. An overall incidence rate of 18.6 per 100 000 livebirths was found, similar to that reported by others. A high male to female ratio (4.32:1) was found; the ratio for non-whites to whites was 1.67:1. Non-white males had the highest rate, 37.6 per 100 000 livebirths. These findings plus the fact that 9% of these children were also diagnosed as having Down's Syndrome, were evidence that the aetiology of Hirschsprung's Disease may be partially genetic. Among environmental factors studied, there was no time trend and no relationship with socioeconomic status found. Among whites, there was a larger percentage of children who were the first births of mothers aged 30 and above, a result previously reported for children with neural tube defects. Very little is known about micro-environmental factors in relation to Hirschsprung's Disease and this would seem to be the area for future emphasis in research.

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先天性巨结肠病的流行病学研究。
在1969年至1977年期间,在马里兰州巴尔的摩市和县出生并在巴尔的摩标准大都会区诊断出的所有新诊断的先天性巨结肠病病例被确定。利用医院记录和死亡证明,确定了33例病例。总发病率为每10万例活产18.6例,与其他报告相似。男女比例高(4.32:1);非白人与白人的比例为1.67:1。非白人男性的死亡率最高,每10万例活产婴儿中有37.6例。这些发现加上这些儿童中9%被诊断患有唐氏综合症的事实,证明了先天性巨结肠病的病因可能部分是遗传的。研究的环境因素中,没有发现时间趋势,与社会经济地位没有关系。在白人中,头胎母亲年龄在30岁及以上的比例更高,此前有报道称这是神经管缺陷儿童的结果。人们对巨结肠病的微环境因素知之甚少,这似乎是未来研究的重点领域。
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来源期刊
International journal of epidemiology
International journal of epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
13.60
自引率
2.60%
发文量
226
审稿时长
3 months
期刊介绍: The International Journal of Epidemiology is a vital resource for individuals seeking to stay updated on the latest advancements and emerging trends in the field of epidemiology worldwide. The journal fosters communication among researchers, educators, and practitioners involved in the study, teaching, and application of epidemiology pertaining to both communicable and non-communicable diseases. It also includes research on health services and medical care. Furthermore, the journal presents new methodologies in epidemiology and statistics, catering to professionals working in social and preventive medicine. Published six times a year, the International Journal of Epidemiology provides a comprehensive platform for the analysis of data. Overall, this journal is an indispensable tool for staying informed and connected within the dynamic realm of epidemiology.
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