{"title":"Age dependent variations in choline and ethanolamine phosphorylating activities of rodents.","authors":"R K Upreti","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The substrate concentration-velocity relationship as influenced by age of animal was determined. At all stages of growth of rat and mouse ethanolamine kinase activity responded with a hyperbolic pattern to substrate concentration. Choline kinase on the other hand, underwent \"enzyme differentiation\". In rat liver up to 4 days of age of animal, in mouse liver up to 7 days and in mouse kidney up to 15 days, choline kinase activity responded with a hyperbolic pattern; but from then onwards the response to substrate concentration was sigmoid. The results obtained pointed to the regulatory nature of choline kinase and a possible distinction between the proteins catalyzing the phosphorylation of the two bases.</p>","PeriodicalId":8818,"journal":{"name":"Biochemistry and experimental biology","volume":"16 3","pages":"221-6"},"PeriodicalIF":0.0000,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemistry and experimental biology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The substrate concentration-velocity relationship as influenced by age of animal was determined. At all stages of growth of rat and mouse ethanolamine kinase activity responded with a hyperbolic pattern to substrate concentration. Choline kinase on the other hand, underwent "enzyme differentiation". In rat liver up to 4 days of age of animal, in mouse liver up to 7 days and in mouse kidney up to 15 days, choline kinase activity responded with a hyperbolic pattern; but from then onwards the response to substrate concentration was sigmoid. The results obtained pointed to the regulatory nature of choline kinase and a possible distinction between the proteins catalyzing the phosphorylation of the two bases.
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