Edmond E. Creppy , Maryvonne Mayer , Daniel Kern , Monique Schlegel , Pieter S. Steyn , Robert Vleggaar , Guy Dirheimer
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引用次数: 11
Abstract
An analogue of valine in which valine is coupled by its amino group to a chlorinated dihydroisocoumarin moiety inhibits competitively the tRNAVal charging with valine catalyzed by pure yeast valyl-tRNA synthetase. The inhibition constant is much lower for the ATPaiPPi exchange reaction than for the tRNA charging one, indicating different rate-determining steps in the two reactions.
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