[Association of mixed connective tissue disease with Sjogren's syndrome and lupus in 2 HLA- and DR-identical sisters].

J Potier, P Freida
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Abstract

Different connective tissue diseases were observed in two HLA--and DR--identical sisters. The daughter of one of the index patients and their father exhibited closely related symptoms. With reference to this familial observation the authors discuss the significance of DR3 which is correlated with immunologic disturbances producing multiple clinical and biological manifestations.

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[2名HLA-和dr -相同姐妹中混合结缔组织病与干燥综合征和狼疮的关系]。
在两个HLA-和DR-相同的姐妹中观察到不同的结缔组织疾病。其中一名患者的女儿与其父亲表现出密切相关的症状。根据这一家族性观察,作者讨论了DR3与产生多种临床和生物学表现的免疫紊乱相关的意义。
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