[Sulfentanil citrate. Administration of intramuscular injections in conscious man (author's transl)].

Anesthesie, analgesie, reanimation Pub Date : 1981-01-01
M Cathelin, R Vignes, A Malki, P Viars
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Abstract

In the case of a conscious man suffering from a painful injury in the facial and trigeminal nerves, the administration of intra-muscular injections of increasing doses of morphine and sulfentanil provokes constant analgesia in direct proportion to the administered dose. The admitted dosages for each product are as follows. M = 0,100, 0,150, 0,200 mg/kg S = 0,00015, 0,0003, 0,0006 mg/kg. Sulfentanil is a highly active analgesic whose activity is about 333 times greater than that of morphine and 13 times greater than that of fentanyl. In the case of each of the 3 products, the point at which analgesia becomes clinically discernable is the same. Optimum intensity of action of the analgesia is arrived at in all 3 cases within a period of 60 to 90 minutes. The higher the dose administered, the longer sulfentanil can be expected to work. Although effective for a shorter period of time than morphine and fentanyl sulfentanil effectiveness is too great for it to be considered a short-acting analgesic.

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[Sulfentanil柠檬酸。清醒者肌内注射的管理[作者简介]。
如果一个有意识的人的面部神经和三叉神经受到了疼痛的伤害,肌肉内注射越来越多的吗啡和磺胺太尼会引起与所给剂量成正比的持续的镇痛。每种产品的允许剂量如下。M = 0,100, 0,150, 0,200 mg/kg S = 0,00015, 0,0003, 0,0006 mg/kg。舒芬太尼是一种高活性镇痛药,其活性约为吗啡的333倍,芬太尼的13倍。在这3种产品的情况下,镇痛成为临床可识别的点是相同的。3例患者均在60 ~ 90分钟内达到最佳镇痛作用强度。剂量越高,预期磺胺太尼起作用的时间越长。虽然有效的时间比吗啡和芬太尼短,但它的有效性太大,不能被认为是一种短效镇痛药。
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