[Levels of serum complement and immunocomplexes in HBs antigen positive blood donors].

Abstract

Blood donors who were tested twice at interval from 6 to 8 months, were HBs-Ag positive both times. The biochemical parameters for the evaluation of liver function were within normal limits. The significantly decreased values of total haemolytic activity of complement-CH50 (0,001) and Clq (0,005) and increased level of Cl Inh (0,005) point ot the activation of the complement system (Table 2, 3). The level of Cl Inh statistically significantly and positively correlates with the values of C4, C5 and with C3A, what means that it participates in the process of activation regulation (Table 5). Using the method of precipitation by means of 0,3 g/l PEG we have registered in 92% of HBs-Ag positive blood donors elevated concentrations of immune complexes and in all PEG precipitates HBs-Ag (Table 6). These findings point to the need of clinical investigation and treatment of those persons.