Bilten za hematologiju i transfuziju最新文献

Study of inverse alloimmunization, previously investigated in HLA-system, was continued by the investigation of maternal--foetal alloimmunization on Gm-system immunoglobulin allotypes (Steinberg-Speiser's phenomenon) in 105 cases of the newborn (cord blood) on antigen determinants of their mothers. The work includes investigation of Gm- and InV-system allotipie, using mothers' and their infants' blood by agglutination inhibition method (according to C. Ropartz and L. Rivat). Later on, using the same method, infants' sensitization to mothers' G-class immunoglobulin specificity was investigated. Allotypes bound to subclasses of G-class immunoglobulins, discrepancy in expression of certain specities of mothers and their infants, possible immaturity of some allotypes at birth and occurrence of immune response in both mother and infant are discussed in this paper. The occurrence we noted is a contribution to investigations of immunoglobulin genetics through Gm-system allotipie bound to protein primary structure.

Investigations included blood donors for extracorporeal circulation, as well as patients (12) before and after cardiopulmonary by-pass. CMV infection is a frequent consequence of multiple fresh blood transfusions in persons with aortocoronary "by-pass" in 25% operated patients. If a patient receives more than 10 transfusions of fresh blood, frequency of serologically positive reactions to CMV is found in approximately 40-60% operated patients. Investigations included 168 healthy individuals, voluntary blood donors, 18-30 years old, both male and female, from various backgrounds and with various occupations. It was found out that amount of antibodies against CMV for men was 42,1% in spring and 66,7% in winter, while the amount of antibodies against CMV for women was 70% in spring and 81% in winter. Complement fixation reaction method was applied.

Paleoserological investigations make possible "biological reconstruction" of old populations and comparison of their characteristics with corresponding characteristics of contemporary population on the same area. The work presents results of the investigation of ABO system blood group distribution from the following archaeological locations: Vlasac (5000 B. C., Mesolithic), Gamzigrad (near Zajecar, III-IV era A. D., Roman period), Vinca (near Grocka, IX era A. D.) and Ras (near N. Pazar, IX-XI era A. D.). At the same time the work presents distribution of ABO blood groups among present population on the same area.

Our experience with cell separator led us to the conclusion that platelet concentration is rather high (6,94 X 10(11)/L), especially in the part of separated blood which contains significant percentage of erythrocytes. A considerable amount of leukocytes (1,6 X 10(10)/L) can be separated as well. It should be mentioned that leukocyte concentrations are significantly higher when Dexan is administered intravenously and Plasmasteril is used. Therapeutic plasmapheresis requires different approach which varies from the usual work with blood donors, since complications can be expected. Appropriate choice of plasma substituents should be made, as well as constant monitoring of electrocardiographic changes in patients.

Blood donation in Socialist Republic of Serbia can be divided into several developing stages which to a certain degree reflect the development and capabilities of blood transfusion service ensuring medical care in this particular domain. Blood donation is voluntary, anonymous and nonremunerated, an expression of the deepest feeling of humanity and interpersonal solidarity. It tends to constant rise and massive participation. Progressive increase in blood donation which ranges between 5 and 10% annually cannot, however, ensure enough blood for an increasingly wide application of component therapy and blood products. Discrepancy between collected and required quantities of blood is evident and it will be overcome when number of donations is increased from present 2,65/100 inhabitants to 5 donations. Consumption of blood per patient varies in different regions. Modern hemotherapy treatment requires well organized and socially directed activities in recruitment of blood donors as a permanent task of blood transfusion service, Red Cross and all other social and political organizations and medical services.