{"title":"Immunological properties of rat embryonal carcinoma cells","authors":"B. Park, L. Van Hove , H. Sobis, M. Vandeputte","doi":"10.1016/0014-2964(81)90262-0","DOIUrl":null,"url":null,"abstract":"<div><p>The reactivity of mouse anti-F9 serum on rat embryonal carcinoma cells (F3/1) and xenogeneic as well as syngeneic host immune responses against F3/1 cells were studied. Mouse anti-F9 serum was reactive on the cell surface of F3/1 cells by immunofluorescence. The same antiserum, however, was not cytotoxic against F3/1 cells. The F3/1 cells were not immunogenic in syngeneic hosts as tested by <em>in vivo</em> and <em>in vitro</em> assays. Thus, in the present study, F3/1 antigen(s) could not be defined with syngeneic antiserum but only defined with non-cytotoxic, surface-binding antibodies (IgG) of xenogeneic anti-F3/1 serum.</p></div>","PeriodicalId":100497,"journal":{"name":"European Journal of Cancer (1965)","volume":"17 6","pages":"Pages 609-613"},"PeriodicalIF":0.0000,"publicationDate":"1981-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0014-2964(81)90262-0","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Cancer (1965)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0014296481902620","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
The reactivity of mouse anti-F9 serum on rat embryonal carcinoma cells (F3/1) and xenogeneic as well as syngeneic host immune responses against F3/1 cells were studied. Mouse anti-F9 serum was reactive on the cell surface of F3/1 cells by immunofluorescence. The same antiserum, however, was not cytotoxic against F3/1 cells. The F3/1 cells were not immunogenic in syngeneic hosts as tested by in vivo and in vitro assays. Thus, in the present study, F3/1 antigen(s) could not be defined with syngeneic antiserum but only defined with non-cytotoxic, surface-binding antibodies (IgG) of xenogeneic anti-F3/1 serum.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
