[Comparative kinetics of spleen cell-mediated antibody-dependent cytotoxic activity in mice treated with BCG or Mycobacterium smegmatis].

Annales d'immunologie Pub Date : 1983-03-01
F Hérodin, D Dormont
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Abstract

Spleen cells from C3H/HeN mice treated with BCG or Mycobacterium smegmatis displayed similar increased antibody-dependent cellular cytotoxicity (ADCC) in vitro. This activity, which increased between the tenth and the thirty-first day after stimulation, reached twice the amount of ADCC activity developed by the control spleen cells. C3H/HeN mice treated with a complete adjuvant including M. smegmatis and squalene displayed a lower increase in their ADCC capacity (30% instead of 100%).

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[卡介苗或耻垢分枝杆菌处理小鼠脾细胞介导的抗体依赖性细胞毒活性的比较动力学]。
用卡介苗或耻垢分枝杆菌处理C3H/HeN小鼠的脾细胞在体外表现出类似的抗体依赖性细胞毒性(ADCC)增加。这种活性在刺激后的第10天至31天之间有所增加,达到对照脾细胞ADCC活性的两倍。C3H/HeN小鼠用包皮鳞芽胞杆菌和角鲨烯的完全佐剂处理后,其ADCC能力的增加较低(30%而不是100%)。
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