Acute effects of a "physiological" dose of 1,25-dihydroxy vitamin D3 on renal phosphate transport.

H Georgaki, J B Puschett
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引用次数: 20

Abstract

The renal phosphate transport response of thyroparathyroidectomized, vitamin D-deficient rats to the infusion of 1,25-dihydroxy vitamin D3 (1,25 D3) was studied with and without the simultaneous administration of a small (or "permissive") non-phosphaturic amount of bovine parathyroid hormone (bPTH). Although phosphate excretion (UPV) was unaltered by the infusion of either 0.1 U (= .0025 microgram or 6 pmoles) of 1,25 D3 or 0.2 U bPTH per hour for 6 hours, their combined administration reduced UPV from 14.8 +/- 1.6 to 10.3 +/- 1.2 microgram/min. (P less than .05). There were no alterations in inulin excretion. These data verify that: 1) 1,25 D3 is antiphosphaturic in this experimental setting in a very low dose which may represent a "physiological" amount of the metabolite; and 2) to enhance phosphate transport, the 1,25 D3 requires the presence of a small ("permissive") amount of PTH.

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“生理”剂量的1,25-二羟基维生素D3对肾磷酸盐运输的急性影响。
研究了切除甲状旁腺、维生素d缺乏的大鼠在输注1,25-二羟基维生素D3 (1,25 D3)的情况下,与不同时给予少量(或“允许”)非磷酸化量的牛甲状旁腺激素(bPTH)的情况下,肾脏磷酸盐转运的反应。尽管每小时输注0.1 U(= 0.0025微克或6 pmol)的1,25 D3或0.2 U bPTH 6小时不会改变磷酸盐排泄(UPV),但它们的联合给药将UPV从14.8 +/- 1.6微克/分钟降低到10.3 +/- 1.2微克/分钟。(P < 0.05)。菊粉的排泄量没有变化。这些数据证实:1)在这个实验环境中,1,25 D3在非常低的剂量下具有抗磷作用,这可能代表代谢物的“生理”量;2)为了增强磷酸盐运输,1,25 D3需要少量(“允许的”)PTH的存在。
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