[Intravenous glucose tolerance and islet cell function following pancreatic duct occlusion in rats (author's transl)].

Abstract

Microsurgery, intraductal pancreatic occlusion by an Ethibloc bolus and intravenous glucose load in the rat enable investigations to be made into the feed-back relationships between occlusion-induced acinar atrophy and the response of the islet hormones insulin, glucagon, somatostatin, and glucose tolerance. Thirteen days after duct occlusion the latter is moderately delayed from 40-60 min, serum insulin is lowered, plasma somatostatin unchanged, and plasma glucagon moderately elevated, as compared with sham-operated control animals. It is suggested that the employed experimental conditions reveal an exo-endocrine pancreatic functional axis, but that the results obtained are not representative for states with an intact entero-insular axis.