Enhancement of rat renal allografts with various immunogens.

Investigative urology Pub Date : 1981-03-01
D C Martin, C W Hewitt
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引用次数: 0

Abstract

Lewis rat recipients of Brown Norway (BN) and Dark Agouti (DA) kidneys were tested for enhanced survival after they were injected with various immunogens. Lewis recipients of BN kidneys injected with either BN whole blood, bone marrow cells, red blood cells, or DA whole blood had enhanced survival. Lewis recipients of BN kidneys injected with either BN plasma or BN thymocytes did not have enhanced survival. Lewis recipients of DN kidneys injected with DA blood had enhanced survival. Lymphocytotoxins were found infrequently in recipients with rejected renal allografts. Active enhancement of the rat renal graft may be produced by immunization with cells that express serum determined or cell determined antigens.

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不同免疫原对大鼠同种异体肾移植的增强作用。
接受褐挪威(BN)和黑鼠(DA)肾脏的Lewis大鼠在注射各种免疫原后,对其存活率进行了测试。Lewis肾受者注射BN全血、骨髓细胞、红细胞或DA全血均可提高生存率。Lewis肾受者注射BN血浆或BN胸腺细胞均未提高生存率。接受DN肾注射DA血的Lewis患者生存率提高。淋巴细胞毒素在排斥的同种异体肾移植受者中很少发现。通过免疫表达血清决定抗原或细胞决定抗原的细胞,可以产生大鼠肾移植物的活性增强。
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