Experimental endocarditis in rabbits. 4. Experiments with Serratia marcescens: on the significance of serum susceptibility and proteolytic capacity of the strains and the influence of an indwelling catheter.

E Gutschik, R S Norwood, S Møller, S Olling
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Abstract

In order to investigate the course of Serratia marcescens endocarditis in groups of rabbits with and without an indwelling catheter, 130 rabbits were pretreated to produce left-sided endocarditis. Three clinical isolates of S. marcescens were used to infect the rabbits, i.e. CDC O13 (serum sensitive, proteolytic), SM 104 (serum resistant, proteolytic) and SM 55 (highly serum resistant, non-proteolytic). Ten rabbits with an indwelling catheter were challenged with CDC O13 and none of them died or showed evidence of endocarditis 28 days later. In groups of rabbits with indwelling catheters which were challenged with SM 104 or SM 55 there was a high incidence of endocarditis (19/20, 18/20, respectively), while groups without catheters inoculated with the same strains had a lower incidence (5/20, 15/20, respectively). In contrast to earlier observations with Streptococcus faecalis, the clinical and pathological data were not significantly influenced by the presence or absence of proteolytic capacity of the infecting strains. The results indicate that the ability of S. marcescens to establish endocarditis depends significantly on the degree of serum resistance of the strains. This difference was only demonstrable in experiments without an indwelling catheter during the infection period. The distrurbing influence of an indwelling catheter is discussed, and it is concluded that experimental models using indwelling catheters are inappropriate for studies on the pathophysiology of endocarditis.

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兔实验性心内膜炎。4. 粘质沙雷菌血清敏感性、蛋白水解能力及留置导管影响的实验研究。
为了观察有和无留置导管家兔粘质沙雷氏菌心内膜炎的病程,对130只家兔进行左侧心内膜炎预处理。采用3株粘质葡萄球菌临床分离株CDC O13(血清敏感,蛋白水解)、SM 104(血清耐药,蛋白水解)和SM 55(血清高度耐药,非蛋白水解)感染家兔。10只家兔留置导管注射CDC O13, 28天后无一死亡或出现心内膜炎。用SM 104或SM 55攻毒留置导管组心内膜炎发生率高(分别为19/20、18/20),未接种相同菌株留置导管组心内膜炎发生率低(分别为5/20、15/20)。与早期对粪链球菌的观察结果相反,临床和病理数据不受感染菌株是否具有蛋白水解能力的显著影响。结果表明,粘质葡萄球菌引起心内膜炎的能力主要取决于菌株的血清抵抗程度。这种差异仅在感染期间没有留置导尿管的实验中得到证实。本文讨论了留置导管的干扰作用,认为留置导管的实验模型不适用于心内膜炎的病理生理研究。
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