Reversed effect of chlorpromazine on hypothalamic serotonin levels of rats with complete deafferentation of the medial basal hypothalamus.

Abstract

The effect of chlorpromazine (CPZ) treatment, the complete deafferentation of the medial basal hypothalamus (MBH) and their combination on 5-HT, DA and NE levels of the MBH, hypothalamic structures outside the MBH (RH), mesencephalon and amygdala were studied. Monoamines were determined by fluorimetry. CPZ reduced 5-HT in the hypothalamus (MBH, RH), DA in the amygdala and NE concentration in the RH. Complete deafferentation of the MBH decreased 5-HT in the MBH, DA in the amygdala and NE in the hypothalamus. CPZ + deafferentation of the MBH increased 5-HT concentrations in the hypothalamus (MBH and RH) and mesencephalon, and depressed DA levels in the amygdala and NE in the hypothalamus. The data suggest that the interruption of the neural connections of the MBH results in an inverse response of the hypothalamic serotoninergic elements to CPZ.