Nonmutagenic activity of the nitroprusside.

Z Bódi, K Antal, J Szabad
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Abstract

The mutagenic activity of the pentacyanonitrosylferrate (II) (NP) was studied by the prophage induction and the Drosophila mosaic test. On the basis of plaque and mosaic spot induction freqauencies it is concluded that both NP and its adenine complex are nonmutagenic as for induction of chromosome breaks and point mutations. The nonmutagenic activity of the NP can be attributed to its nonpermeability through cell membranes.

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硝普苷的非诱变活性。
采用噬菌体诱导和果蝇嵌合实验研究了五氰硝基高铁酸盐(NP)的诱变活性。根据斑块和花叶斑的诱导频率,可以得出结论,NP及其腺嘌呤复合物在诱导染色体断裂和点突变方面具有非诱变性。NP的非诱变活性可归因于其不透过细胞膜的渗透性。
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