Ganglioside content and pattern in tumor tissue of human neuroblastomas.

N Baumann, M L Harpin, J C Turpin
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Abstract

The ganglioside content and composition in human neuroblastomas was examined. The densitometric pattern corresponding to the thin-layer chromatography of gangliosides showed no major differences compared to normal brain in the GT area, and variable modifications for GM1 and GD3. The most striking and common features resided in the area corresponding to the disialogangliosides for which is was clear that existed a far more complex pattern than normal human brain.

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人神经母细胞瘤肿瘤组织中神经节苷脂的含量和模式。
研究了人神经母细胞瘤中神经节苷脂的含量和组成。与神经节苷脂薄层色谱相对应的密度图显示,与正常脑相比,GT区没有明显差异,GM1和GD3发生了变化。最引人注目和最常见的特征存在于与双联神经节苷脂相对应的区域,很明显,在这个区域存在着比正常人大脑复杂得多的模式。
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