[Are prostaglandins important in the development of gastric mucosal lesions following hemorrhagic shock? (author's transl)].

Abstract

PGE2, 13,14-dihydro-15-keto PGF2 alpha (DHK-PGF2 alpha) and PGF2 alpha were determined in arterial, central-venous and postgastric-venous plasma in a hemorrhagic shock model in mini pigs. PGE2 and DHK-PGF2 alpha significantly increased in all samples; highest values could be measured in postgastric-venous plasma, less in arterial, least in central-venous plasma. The ratio DHK-PGF2 alpha/PGF2 alpha was significantly increased during hemorrhagic shock in comparison with controls. A protective effect of certain E- and F-prostaglandins on gastric mucosa during hemorrhagic shock is assumed.