G Matullo, R M Griffo, J L Mountain, A Piazza, L L Cavalli-Sforza
{"title":"RFLP analysis on a sample from northern Italy.","authors":"G Matullo, R M Griffo, J L Mountain, A Piazza, L L Cavalli-Sforza","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>We analysed a sample of 55 unrelated individuals from Trino Vercellese, a village in northern Italy. It represents the only European sample which is unmixed in a comparative study of eight populations from four continents [Bowcock et al 1991a; Lin et al 1994]. RFLP analysis was performed on 32 DNA markers, for a total of 37 independent alleles. Genetic variability between populations was measured by the FST statistics (average FST is 0.138). Average heterozygosity was calculated for each marker and for each population. Genetic distances were evaluated between pairs of populations. Phylogenetic trees were reconstructed and principal component analysis performed.</p>","PeriodicalId":77141,"journal":{"name":"Gene geography : a computerized bulletin on human gene frequencies","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gene geography : a computerized bulletin on human gene frequencies","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
We analysed a sample of 55 unrelated individuals from Trino Vercellese, a village in northern Italy. It represents the only European sample which is unmixed in a comparative study of eight populations from four continents [Bowcock et al 1991a; Lin et al 1994]. RFLP analysis was performed on 32 DNA markers, for a total of 37 independent alleles. Genetic variability between populations was measured by the FST statistics (average FST is 0.138). Average heterozygosity was calculated for each marker and for each population. Genetic distances were evaluated between pairs of populations. Phylogenetic trees were reconstructed and principal component analysis performed.
我们分析了来自意大利北部村庄Trino Vercellese的55个不相关个体的样本。它代表了来自四大洲的八个人群的比较研究中唯一未混合的欧洲样本[Bowcock等，1991a;Lin et al . 1994]。对32个DNA标记进行RFLP分析，共获得37个独立等位基因。种群间遗传变异采用FST统计(平均FST为0.138)。计算每个标记和每个群体的平均杂合度。对群体间的遗传距离进行了评价。重建系统发育树并进行主成分分析。
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