L Steardo, M D Steardo, M Mazzoccoli, N Testa, V Cuomo
{"title":"Selective activation of glutamate receptor NMDA subtype induces plasma vasopressin increase in rats.","authors":"L Steardo, M D Steardo, M Mazzoccoli, N Testa, V Cuomo","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Studies were carried out in the rat to investigate whether glutamic acid is involved in the regulation of vasopressin (VP) release. For this purpose plasma VP levels were measured in rats treated with the glutamate agonist N-methyl-D-aspartate (NMDA). In our experimental conditions NMDA induced dose-related increases in plasma VP levels in normohydrated rats. The effect of NMDA were prevented by 3[(+)-2 carboxy-piperazine-4-yl]propyl-1-phosphonic acid (CPP), a selective and competitive antagonist of NMDA receptors. These data show that glutamate may contribute to the physiological release of VP from the neurohypophysis.</p>","PeriodicalId":6970,"journal":{"name":"Acta neurologica","volume":"16 5-6","pages":"235-9"},"PeriodicalIF":0.0000,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta neurologica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Studies were carried out in the rat to investigate whether glutamic acid is involved in the regulation of vasopressin (VP) release. For this purpose plasma VP levels were measured in rats treated with the glutamate agonist N-methyl-D-aspartate (NMDA). In our experimental conditions NMDA induced dose-related increases in plasma VP levels in normohydrated rats. The effect of NMDA were prevented by 3[(+)-2 carboxy-piperazine-4-yl]propyl-1-phosphonic acid (CPP), a selective and competitive antagonist of NMDA receptors. These data show that glutamate may contribute to the physiological release of VP from the neurohypophysis.
在大鼠身上进行了研究，以探讨谷氨酸是否参与调节抗利尿激素(VP)的释放。为此，用谷氨酸激动剂n -甲基- d -天冬氨酸(NMDA)治疗大鼠，测量血浆VP水平。在我们的实验条件下，NMDA诱导了正常水合大鼠血浆VP水平的剂量相关升高。NMDA受体的选择性和竞争性拮抗剂3[(+)-2羧基哌嗪-4-基]丙基-1-膦酸(CPP)可抑制NMDA的作用。这些数据表明谷氨酸可能有助于脑垂体VP的生理释放。
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