{"title":"Nanosensors and their applications in early diagnosis of cancer","authors":"Masoud Khazaei , Marzieh Sadat Hosseini , Ali Moshfegh Haghighi , Majid Misaghi","doi":"10.1016/j.sbsr.2023.100569","DOIUrl":null,"url":null,"abstract":"<div><p>According to WHO and other key statistics, cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020. By identifying cancer early, it is more likely to respond to treatment, resulting in a better chance of survival as well as a lower cost of treatment. Early detection of cancer and avoiding delays in treatment can significantly improve the lives of cancer patients. Nanomaterial-based sensors with the ability to extract and identify tumor-specific biomarkers, circulating tumor cells, or extracellular vesicles secreted by the tumor have the potential to diagnose cancer considerably earlier and enhance patient long-term survival. In this review, we provide the application of nanosensors for the early detection of cancer and the recent techniques for clinically diagnosing cancer patients' biomarker levels. Furthermore, the presented works are compared based on their sensitivity and selectivity in the detection of different kinds of cancer biomarkers.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"41 ","pages":"Article 100569"},"PeriodicalIF":5.4000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sensing and Bio-Sensing Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214180423000211","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 4
Abstract
According to WHO and other key statistics, cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020. By identifying cancer early, it is more likely to respond to treatment, resulting in a better chance of survival as well as a lower cost of treatment. Early detection of cancer and avoiding delays in treatment can significantly improve the lives of cancer patients. Nanomaterial-based sensors with the ability to extract and identify tumor-specific biomarkers, circulating tumor cells, or extracellular vesicles secreted by the tumor have the potential to diagnose cancer considerably earlier and enhance patient long-term survival. In this review, we provide the application of nanosensors for the early detection of cancer and the recent techniques for clinically diagnosing cancer patients' biomarker levels. Furthermore, the presented works are compared based on their sensitivity and selectivity in the detection of different kinds of cancer biomarkers.
期刊介绍：
Sensing and Bio-Sensing Research is an open access journal dedicated to the research, design, development, and application of bio-sensing and sensing technologies. The editors will accept research papers, reviews, field trials, and validation studies that are of significant relevance. These submissions should describe new concepts, enhance understanding of the field, or offer insights into the practical application, manufacturing, and commercialization of bio-sensing and sensing technologies.
The journal covers a wide range of topics, including sensing principles and mechanisms, new materials development for transducers and recognition components, fabrication technology, and various types of sensors such as optical, electrochemical, mass-sensitive, gas, biosensors, and more. It also includes environmental, process control, and biomedical applications, signal processing, chemometrics, optoelectronic, mechanical, thermal, and magnetic sensors, as well as interface electronics. Additionally, it covers sensor systems and applications, µTAS (Micro Total Analysis Systems), development of solid-state devices for transducing physical signals, and analytical devices incorporating biological materials.
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