Sensing and Bio-Sensing Research最新文献

Development of a poly (alizarin red S)/EDTA/GCE sensor for rapid and reliable monitoring of methyl parathion pesticide 聚茜素红S /EDTA/GCE传感器快速可靠监测农药中甲基对硫磷的研制

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2025-12-05 DOI: 10.1016/j.sbsr.2025.100938

Andualem Ejigu , Molla Tefera , Adisie Kassa , Atnafu Guadie

Methyl parathion (MP) is a powerful organophosphate insecticide commonly used in agriculture, but it poses serious risks to both human health and environmental safety. This study presents a highly sensitive electrochemical sensor development based on a glassy carbon electrode (GCE) that has been modified in sequence with Ethylenediaminetetraacetic acid (EDTA) and electropolymerized with poly(Alizarin Red S) (poly(ARS)) for detecting MP. The poly(ARS)/EDTA/GCE was characterized with cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The EDTA improves the surface functionality and adhesion, while the redox-active poly(ARS) film aids in electron transfer and offers selective sites for MP interaction. The sensor showed significantly better stability, catalytic performance, and electroactive surface area compared to the unmodified electrode.

Under optimized pH of 7.0, the sensor reached a limit of detection (LOD) of 0.5527 μM, a limit of quantification (LOQ) of 1.8425 μM, and a linear range from 0.05 to 140 μM, with a sensitivity of 0.1265 μA/μM. It exhibited excellent analytical capabilities, such as repeatability with a relative standard deviation (RSD) of 2.01 %, reproducibility across five independently crafted electrodes with an RSD of 3.13 %, and operational stability over five days with an RSD of 1.76 %. The practical utility of the sensor was validated through MP recovery studies on fresh vegetable samples, which achieved recoveries ranging from 98 % to 113 %.

In summary, the developed poly(ARS)/EDTA/GCE sensor provides an effective and reliable method for monitoring MP in both environmental and food safety contexts.

甲基对硫磷（Methyl parathion， MP）是一种农业常用的强效有机磷杀虫剂，但对人体健康和环境安全造成严重危害。本研究提出了一种基于玻璃碳电极（GCE）的高灵敏度电化学传感器，该电极经乙二胺四乙酸（EDTA）顺序修饰，并与聚茜素红S（聚（ARS））电聚合，用于检测MP。用循环伏安法（CV）和电化学阻抗谱（EIS）对聚(ARS)/EDTA/GCE进行了表征。EDTA改善了表面功能和粘附性，而氧化还原活性聚（ARS）膜有助于电子转移，并为MP相互作用提供了选择性位点。与未修饰的电极相比，该传感器表现出更好的稳定性、催化性能和电活性表面积。优化后的pH为7.0时，传感器的检出限为0.5527 μM，定量限为1.8425 μM，线性范围为0.05 ~ 140 μM，灵敏度为0.1265 μA/μM。它具有出色的分析能力，如重复性，相对标准偏差（RSD）为2.01%，重复性在5个独立制作的电极上，RSD为3.13%，5天内的操作稳定性，RSD为1.76%。通过对新鲜蔬菜样品的MP回收率研究，验证了该传感器的实用性，其回收率为98% ~ 113%。综上所述，所开发的聚(ARS)/EDTA/GCE传感器为环境和食品安全背景下的MP监测提供了一种有效可靠的方法。

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引用次数: 0

Influence of light incidence angle and polarization on the refractive index sensitivity of tightly-packed ellipsoidal gold nanoparticle layers 光入射角和偏振对致密填充椭圆型金纳米颗粒层折射率灵敏度的影响

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2025-11-27 DOI: 10.1016/j.sbsr.2025.100924

Rebeka Kovács , Lóránt Tibor Csőke , Tomáš Lednický , Attila Bonyár

The effect of excitation angle and polarization on the bulk refractive index sensitivity (RIS) of hexagonally-arranged gold nanoparticles is studied through numerical simulations and experiments. Analytical approximations (based on Rayleigh-Gans theory) and boundary element method (BEM) simulations proved that the RIS of single ellipsoidal particles depends intrinsically on the illumination angle. Compared to normal incidence with linear polarization, the RIS increases by 5–10 % at 70° incidence angle, depending on the particle geometry. Finite element method (FEM) simulations explored near-field coupling in tightly-packed particle assemblies and the effect of a substrate beneath the nanoparticles. The simulations showed that coupling between the particles significantly improves the sensitivity to the incidence angle, resulting in a 17–25 % increase in RIS at 70° illumination compared to normal incidence. Experiments performed on three realized nanoparticle arrangements with varying particle density were carried out in a transmission-based setup with linear, circular polarization, and unpolarized light. Results show significantly increased RIS in the 60°<

θ

<75° incidence angle range, namely between a 12–35 % improvement compared to normal incidence, depending on the particle density. These results underline the importance of optimizing the excitation parameters to maximize the sensitivity of nanoplasmonic sensors for localized surface plasmon resonance (LSPR) applications.

通过数值模拟和实验研究了激发角和极化对六边形排列金纳米粒子体折射率灵敏度的影响。解析近似（基于瑞利-甘斯理论）和边界元法（BEM）模拟证明了单椭球粒子的RIS本质上依赖于光照角度。与线偏振法入射相比，在70°入射角时，RIS增加了5 - 10%，具体取决于粒子的几何形状。有限元方法（FEM）模拟探讨了近场耦合在紧密堆积的颗粒组件和衬底下的纳米颗粒的影响。模拟结果表明，粒子之间的耦合显著提高了对入射角的敏感性，在70°照明下，与正常入射角相比，RIS增加了17 - 25%。在线性、圆偏振光和非偏振光的传输装置中，对三种不同颗粒密度的纳米颗粒排列进行了实验。结果表明，在60°<； θ <；75°入射角范围内，RIS显著增加，即与正常入射角相比，RIS提高了12 - 35%，具体取决于颗粒密度。这些结果强调了优化激发参数以最大化局部表面等离子体共振（LSPR）应用中纳米等离子体传感器灵敏度的重要性。

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引用次数: 0

From muscle potentials to computer interfaces: A multiscale review of electromyography for clinical and computational applications 从肌肉电位到计算机接口：临床和计算应用的肌电图多尺度回顾

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2026-01-28 DOI: 10.1016/j.sbsr.2026.100969

Vibha Tiwari , Suyash Khare , Krishna Sharma , Ansh Shrivastava , Rebakah Geddam , Muhammad Awais , Muhammad Ahmed Khan , Hemant Ghayvat

EMG has been developed as a result of the early physiological experimentation into a primary modality of neuromuscular function characterization, clinical diagno-sis, rehabilitation planning, and human-machine interface. This Review summarizes the history, methodological basis, and computational advances, as well as biomedical applications of EMG, along the entire acquisition-to-interpretation spectrum. The discussion will follow the historical process of increasing the sophistication of early biophysical measurements through surface and intramuscular recording paradigmsthe relevant engineering optimizations, such as optimizing electrode to skin inter-face, signal conditioning, artifact reduction, sampling fidelity, and normalization processes, that cumulatively realize the modern high-quality EMG recording. The review also summarizes the wide range of clinical and biomedical areas influenced by EMG such as the electrophysiological diagnostics, motor control mea-sures, movement-disorder measurements, neuroprosthetic and exoskeletal controls, and the neurorehabilitation based on biofeedback. The advances in analytics are discussed extensively, including handcrafted temporal, spectral and time-frequency representations; hybrid feature-fusion approaches; classical machine-learning classi-fication paradigms and more recent developments in deep learning, transfer learning, through this synthesis, the Review will provide a rigorous and thorough platform of advances that can further advance EMG to highly intelligent, adaptive, and clinically embedded applications in modern biomedicine.

作为早期生理学实验的结果，肌电图已经发展成为神经肌肉功能表征、临床诊断、康复计划和人机界面的主要方式。这篇综述总结了肌电图的历史，方法基础，计算的进步，以及生物医学应用，沿着整个采集到解释的范围。讨论将遵循通过表面和肌肉内记录范式增加早期生物物理测量复杂性的历史过程，以及相关的工程优化，例如优化电极到皮肤界面，信号调理，伪影减少，采样保真度和标准化过程，这些过程累积实现了现代高质量的肌电图记录。综述了肌电图在电生理诊断、运动控制测量、运动障碍测量、神经义肢和外骨骼控制以及基于生物反馈的神经康复等临床和生物医学领域的广泛影响。广泛讨论了分析的进展，包括手工制作的时间、频谱和时频表示；混合特征融合方法；经典的机器学习分类范式和深度学习、迁移学习的最新发展，通过这种综合，该综述将提供一个严格而彻底的进展平台，可以进一步推动肌电图在现代生物医学中的高度智能、自适应和临床嵌入式应用。

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引用次数: 0

Molecularly imprinted polymer-based biosensors for tetracyclines detection: Principles, applications, and emerging trends 四环素检测分子印迹聚合物生物传感器：原理，应用和新兴趋势

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2026-02-17 DOI: 10.1016/j.sbsr.2026.100981

Chau Nguyen Minh Hoang , Son Hai Nguyen , Andrew W. Taylor-Robinson , Cuong Danh Do , Mai Thi Tran

Tetracyclines (TCs) are a group of bacterial protein synthesis inhibitors considered as broad-spectrum antibiotics, which are widely deployed in human and veterinary medicine, aquaculture, and agriculture. Their overuse leaves residues in foods and waters and accelerates the spread of antibiotic-resistant bacteria and resistance genes. As a result, the need for sensitive and selective detection of TCs in complex matrices has become increasingly important. Molecularly imprinted polymer (MIP)-based biosensors have emerged as a promising analytical platform, known for their high specificity, cost-effectiveness, and adaptability to various transduction methods. This review synthesizes recent advancements in MIP-based biosensors for the detection of TC residues, with emphasis on applications in food safety and environmental monitoring. We examine a range of transduction strategies, including electrochemical, fluorescence, and colorimetric methods, evaluating their analytical performance, practicality, and suitability for real-world scenarios. Particular attention is placed on food matrices, such as milk and meat, as well as environmental samples, like river water and livestock waste. Our findings underscore the significant potential of MIP-based biosensors to enhance the monitoring and regulation of TC residues, thereby supporting key initiatives aimed at One Health framework and contributing to several United Nations Sustainable Development Goals (SDGs), including Good Health and Well-Being (SDG 3), Clean Water and Sanitation (SDG 6), Life Below Water (SDG 14), and Life on Land (SDG 15).

四环素是一类被认为是广谱抗生素的细菌蛋白合成抑制剂，广泛应用于人兽医学、水产养殖和农业等领域。它们的过度使用会在食物和水中留下残留物，加速耐抗生素细菌和耐药基因的传播。因此，对复杂基质中tc的敏感和选择性检测变得越来越重要。基于分子印迹聚合物（MIP）的生物传感器以其高特异性、成本效益和对各种转导方法的适应性而闻名，已成为一种有前途的分析平台。本文综述了基于mip的生物传感器检测TC残留的最新进展，重点介绍了其在食品安全和环境监测中的应用。我们研究了一系列的转导策略，包括电化学、荧光和比色法，评估了它们的分析性能、实用性和对现实世界场景的适用性。特别注意的是食物基质，如牛奶和肉类，以及环境样本，如河水和牲畜粪便。我们的研究结果强调了基于mip的生物传感器在加强TC残留物监测和调控方面的巨大潜力，从而支持旨在实现“一个健康”框架的关键举措，并为几个联合国可持续发展目标（SDG）做出贡献，包括良好的健康和福祉（SDG 3）、清洁水和卫生（SDG 6）、水下生命（SDG 14）和陆地生命（SDG 15）。

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引用次数: 0

An easy-to-use nucleic acid-based fluidic platform for the profiling of oral microbiome from swab and mouthwash that consists of functionalized microbeads and a multi-chamber aliquoting structure 一种易于使用的基于核酸的流体平台，用于从拭子和漱口水中分析口腔微生物组，该平台由功能化微珠和多室ali引述结构组成

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2025-11-27 DOI: 10.1016/j.sbsr.2025.100931

Hyejin Lee , Yun Guang Li , Jiatong Kang , Seung Won Shin , Changyoon Baek , Junhong Min

The oral microbiome is an important indicator of health status; however, it has the limitation of varying significantly over time and under different life conditions. Therefore, rapid and convenient analysis through automation is required. In this study, we developed an automated oral microbiome analysis platform for the rapid and convenient diagnosis of health using mouthwash as the sample. Functionalized microbeads coated with graphene oxide (GO) were employed to concentrate 5 mL of mouthwash sample into 300 μL within 3 min, achieving an eight-fold concentration. Effective adsorption of bacteria onto the functionalized microbeads was confirmed using scanning electron microscopy. Furthermore, nucleic acids were extracted from bacteria adsorbed on the functionalized microbeads via bead beating (3000 rpm) for 3 min, achieving approximately 100 % yield compared with conventional methods. The extracted nucleic acid solution was then automatically aliquoted into PCR 8-tube strips (2 μL each) with high accuracy (CV% = 2.63 %) using a simple fluidic aliquoting structure that incorporated an access channel and retention area. Oral microbiome profiling at the phylum level was compared between the developed fluidic cartridge method and commercial approaches, including next-generation sequencing (NGS) analysis. The automated platform, which integrates the developed sample pretreatment and aliquoting processes into a fluidic cartridge, successfully analyzed the oral health status of both humans and companion animals within 3 h, demonstrating analytical accuracy equivalent to that of NGS.

口腔微生物群是健康状况的重要指标；然而，在不同的寿命条件下，随着时间的推移，它有显著变化的局限性。因此，需要通过自动化进行快速方便的分析。在这项研究中，我们开发了一个口腔微生物组自动分析平台，以漱口水为样本快速方便地诊断健康状况。用涂有氧化石墨烯（GO）的功能化微珠将5 mL漱口水样品在3 min内浓缩至300 μL，浓度达到8倍。用扫描电镜证实了细菌在功能化微珠上的有效吸附。此外，通过加热（3000转/分）3分钟，从吸附在功能化微珠上的细菌中提取核酸，与传统方法相比，收率约为100%。将提取的核酸液自动引到PCR 8管条（每条2 μL）上，准确度高（CV% = 2.63%），采用带有通道和保留区的简易流控引液结构。在门水平上比较了开发的流体盒方法和商业方法（包括下一代测序（NGS）分析）之间的口腔微生物组分析。该自动化平台将开发的样品前处理和ali引述过程集成到一个流体盒中，成功地在3小时内分析了人类和伴侣动物的口腔健康状况，其分析精度相当于NGS。

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引用次数: 0

SPR biosensors based on low-dimensional carbon materials for trace urine glucose 基于低维碳材料的微量尿糖SPR生物传感器

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2025-12-04 DOI: 10.1016/j.sbsr.2025.100935

Talia Tene , Jessica Alexandra Marcatoma Tixi , Ximena Alexandra Quintana López , Lala Gahramanli , Rana Khankishiyeva , Cristian Vacacela Gomez

Surface plasmon resonance (SPR) biosensors are attractive for non-invasive screening of urine glucose, but their performance depends sensitively on the choice of low-dimensional carbon overlayer and metal stack. Here we numerically compare graphene, semiconducting single-walled carbon nanotubes SWCNT (s-SWCNT), graphene oxide (GO), or reduced graphene oxide (rGO) integrated in a standardized CaF₂/Cu/Si₃N₄/(low-D)/urine stack. Using a transfer-matrix model at 633 nm, with a realistic analyte refractive index change (Δn ≈ 4.6 × 10⁻⁴ RIU) corresponding to 0.015–0.225 g dL⁻¹ urine glucose, we extract angular sensitivity, linewidth, quality factor, figure of merit, a combined sensitivity factor and theoretical limits of detection. Within an effective-medium description of the carbon films, rGO delivers the highest sensitivity and lowest detection limits but broader resonance dips; GO yields the narrowest dips and the highest precision; graphene and s-SWCNTs offer intermediate responses with stable linewidths and minimal angle drift. We also identify practical thickness windows for each overlayer on Cu that balance sensitivity against spectral sharpness. Compared with prior SPR studies that focus on a single carbon coating or Au-based stacks, this work provides a unified framework and quantitative design rules to select Cu-based low-dimensional overlayers for resolving small, bulk urine-glucose-induced refractive-index changes above the clinical baseline and to guide subsequent experimental implementations.

表面等离子体共振（SPR）生物传感器在无创筛选尿糖方面具有吸引力，但其性能敏感地取决于低维碳层和金属堆的选择。在这里，我们在数值上比较了石墨烯、半导体单壁碳纳米管SWCNT （s-SWCNT）、氧化石墨烯（GO）或还原氧化石墨烯（rGO）集成在标准化的CaF₂/Cu/Si₃N₄/（低d）/尿液堆中。在633 nm处使用传递矩阵模型，实际分析物折射率变化（Δn≈4.6 × 10−4 RIU）对应0.015-0.225 g dL−1尿糖，我们提取了角灵敏度、线宽、质量因子、优值、组合灵敏度因子和理论检出限。在碳膜的有效介质描述中，还原氧化石墨烯提供了最高的灵敏度和最低的检测限，但更宽的共振倾角；氧化石墨烯产生最小的倾角和最高的精度；石墨烯和s-SWCNTs提供了稳定的线宽和最小角度漂移的中间响应。我们还确定了Cu上每个覆盖层的实际厚度窗口，以平衡灵敏度与光谱清晰度。与以往的SPR研究相比，这项工作提供了一个统一的框架和定量设计规则，以选择基于cu的低维覆盖层来解决超过临床基线的小批量尿葡萄糖诱导的折射率变化，并指导后续的实验实施。

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引用次数: 0

Electrochemical molecularly imprinted polymer (MIP) sensor for progressive monitoring of antibody production ex vivo 电化学分子印迹聚合物（MIP）传感器用于体外抗体生产的渐进监测

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2026-03-03 DOI: 10.1016/j.sbsr.2026.100991

Kyung Eun You, Joshua Cheng, Jeong Ok Lim, James J. Yoo, Sang Jin Lee, Shay Soker

Dynamic monitoring of antibody production is essential for understanding immune responses. Conventional assays like ELISA offer only static measurements and lack temporal representation. To address this limitation, we developed an electrochemical biosensor using molecularly imprinted polymers (MIPs) for rapid, label-free detection of immunoglobulins (IgGs). Our platform enables progressive assessment of IgG production ex vivo through sequential electrochemical measurements. The MIP sensor was fabricated via electropolymerization of o-phenylenediamine and pyrrole in the presence of the Fc fragment of IgG as a template. Selective IgG recognition cavities were formed through combined chemical and electrochemical template removal. An ex vivo platform was established using hybridoma cells encapsulated in hydrogel beads to simulate continuous antibody production over seven days. The sensor detected mouse IgG in the range of 1.56–50 ng/mL with a strong linearity (R² = 0.956) and a limit of detection of 1.54 ng/mL, and it also demonstrated the capability to detect IgG in human serum samples. IgG production was progressively monitored in hybridoma culture medium, with temporal trends consistent with ELISA measurements. By Day 7, the ratio of IgG concentration measured by the MIP sensor to that determined by ELISA was approximately 0.95. This study demonstrates the feasibility of the MIP sensor for fast, label-free IgG detection, providing a practical and efficient platform alternative to traditional assays.

动态监测抗体的产生对于理解免疫反应是必不可少的。像ELISA这样的传统检测方法只能提供静态测量，缺乏时间表征。为了解决这一限制，我们开发了一种使用分子印迹聚合物（MIPs）的电化学生物传感器，用于快速，无标记检测免疫球蛋白（igg）。我们的平台可以通过连续的电化学测量来逐步评估体内IgG的产生。以IgG的Fc片段为模板，通过邻苯二胺和吡咯的电聚合制备了MIP传感器。通过化学和电化学联合去除模板形成选择性IgG识别空腔。用包被水凝胶珠的杂交瘤细胞建立离体平台，模拟连续7天的抗体产生。该传感器对小鼠IgG的检测范围为1.56 ~ 50 ng/mL，线性关系良好（R2 = 0.956），检出限为1.54 ng/mL，对人血清样品中的IgG也具有检测能力。在杂交瘤培养基中逐步监测IgG的产生，其时间趋势与ELISA测量结果一致。第7天，MIP传感器测得的IgG浓度与ELISA测定的IgG浓度之比约为0.95。本研究证明了MIP传感器用于快速、无标记IgG检测的可行性，为传统检测提供了一个实用、高效的平台。

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引用次数: 0

Waveform-aware deep learning for quantitative agglutination on a low-cost lab-in-tubing microfluidic platform 基于低成本管内实验室微流控平台的定量凝集的波形感知深度学习

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2026-02-19 DOI: 10.1016/j.sbsr.2026.100983

Rohith Jayaraman Krishnamurthy, Justin Farrell, Abdul Basit Zia, Abbas S. Milani, Ian G. Foulds

Objective

To enable quantitative agglutination readout using an ultra-low-cost (parts cost < $40) lab-in-tubing optical platform.

Methods

Droplet waveforms were recorded with dual infrared line-break sensors from biotinylated BSA mixed with streptavidin-coated beads at nine levels (0, 0.0128–1000 μg mL-1; N = 223 droplets, N = 211 after QC). We apply waveform-aware preprocessing (i.e., preprocessing operations defined on the full time-series waveform that preserve concentration-dependent morphology rather than reducing the signal to a single scalar) (length normalization, Hampel spike suppression, offset-drift compensation, quality-control filtering, and blank (0 μg mL-1) reference subtraction) and train a one-dimensional convolutional neural network (1D-CNN) to regress log10(concentration). Results: On a stratified 80/20 validation split, the model achieved MAE = 30.49 μg mL-1 with sub-μg absolute errors at trace-to-mid concentrations and larger but scale-appropriate deviations near the apex (∼8 μg mL-1) and in the prozone. Leave-one-concentration-out (LOCO) experiments show that errors increase primarily at omitted calibration anchors, motivating a minimal three-anchor scheme (low, apex, high/prozone) for stable interpolation. Conclusion: Coupling inexpensive optics with waveform-level modeling supports quantitative agglutination estimation across nearly five orders of magnitude (0.0128–1000 μg mL-1). Multi-day, multi-device, and matrix-effect validation remain future work. LOCO is a special case of leave-group-out cross-validation, and we use it here to emulate missing calibration anchors.

目的利用超低成本（零件成本40美元）的试管实验室光学平台实现定量凝集读数。方法将生物素化的牛血清白蛋白与链霉亲和素包被微球（0,0.0128 ~ 1000 μg mL-1; N = 223滴，QC后N = 211滴）混合，用双红外断线传感器记录微滴波形。我们应用波形感知预处理（即，在完整时间序列波形上定义的预处理操作，保留浓度相关的形态，而不是将信号减少到单个标量）（长度归一化，Hampel spike抑制，偏移漂移补偿，质量控制滤波和空白（0 μg mL-1）参考减法），并训练一维卷积神经网络（1D-CNN）回归log10（浓度）。结果：在80/20的分层验证分割下，该模型在痕量至中浓度处的MAE = 30.49 μg mL-1，绝对误差为亚μg，在接近顶点处和在prozone处的偏差较大，但与尺度相适应（~ 8 μg mL-1）。留一浓度（LOCO）实验表明，误差主要在省略的校准锚点处增加，从而激发了最小的三锚点方案（低，顶点，高/prozone）以实现稳定的插值。结论：将廉价光学与波形级建模相结合，支持近5个数量级（0.0128-1000 μg mL-1）的定量凝集估计。多天、多设备和基质效应验证仍然是未来的工作。LOCO是leave-group-out交叉验证的一种特殊情况，我们在这里使用它来模拟缺失的校准锚。

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引用次数: 0

Experimental and finite element analysis of coil position effects in inductive sensors using a design of experiments approach 采用实验设计的方法对电感式传感器线圈位置效应进行了实验和有限元分析

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2026-02-19 DOI: 10.1016/j.sbsr.2026.100985

Morteza Bagheri, Amir Musa Abazari

Planar coils offer advantages such as a two-dimensional structure and compact design, making them suitable for various applications. They are widely used in position sensing, proximity detection, and non-contact measurement. Planar coils rely on mutual inductance as a key parameter. The mutual inductance changes with the relative displacement between two coils. The mutual inductance variation is the basis of inductive sensors. This study includes both experimental and finite element investigations of the effect of coil displacement on mutual inductance. In the experimental setup, a special fixture was designed to enable the movement of one coil with six degrees of freedom, allowing precise control of both axial and angular displacements. First, the accuracy of the finite element model was validated by comparing its results with those from a reference study, yielding an R² score between 0.9377 and 0.9721. The mutual inductance between two coils was evaluated under different conditions using both methods. The Taguchi method was employed to reduce the number while maintaining accuracy. The signal-to-noise ratio analysis showed that minimizing the vertical gap between the coils enhances magnetic coupling, while x-axis rotation has the least effect.

平面线圈具有二维结构和紧凑设计等优点，适用于各种应用。它们广泛应用于位置传感、接近检测和非接触式测量。平面线圈依靠互感作为关键参数。互感随两个线圈之间的相对位移而变化。互感变化是电感式传感器的基础。本研究包括线圈位移对互感影响的实验和有限元研究。在实验装置中，设计了一个特殊的夹具，使一个线圈的运动具有六个自由度，从而可以精确控制轴向和角位移。首先，通过将有限元模型的结果与参考研究的结果进行比较，验证了有限元模型的准确性，得到R2评分在0.9377 ~ 0.9721之间。用这两种方法对不同条件下线圈间的互感进行了计算。采用田口法在保持精度的同时减少了数目。信噪比分析表明，减小线圈之间的垂直间隙可以增强磁耦合，而x轴旋转对磁耦合的影响最小。

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引用次数: 0

Bio-inspired linseed derived carbon quantum dots as a fluorescent probe for the fluorimetric determination of imeglimin in biological fluids and dosage forms 生物启发亚麻籽衍生的碳量子点作为荧光探针，用于荧光测定生物液体和剂型中的伊米霉素

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2025-12-20 DOI: 10.1016/j.sbsr.2025.100946

Aya Barseem , Reem H. Obaydo , Samar H. Elagamy

This study demonstrates the first fluorimetric method for the determination of Imeglimin IMG, a novel antidiabetic drug. Since IMG lacks native fluorescence, a novel bio-inspired linseed derived carbon quantum dots LIN-CQDs were utilized as a fluorescent probe for its determination. The LIN-CQDs exhibited strong native emission at 470 nm upon excitation at 380 nm. Comprehensive characterization of the synthesized LIN-CQDs was performed using transmission electron microscopy TEM, energy-dispersive X-ray spectroscopy EDX, and X-ray photoelectron spectroscopy XPS, which confirmed the successful formation of nitrogen-doped CQDs. The fluorescence intensity of LIN-CQDs was quenched progressively with increasing concentrations of IMG. The mechanism of quenching was studied and it was found to follow a static quenching process. The quenching response showed excellent linearity over the concentration range of 0.15–3.0 μg/mL. All experimental conditions influencing the quenching process were carefully optimized. The method was validated in compliance with ICH guidelines, demonstrating high accuracy, precision, and specificity. The results of statistical comparison with a previously reported HPLC method confirmed no evident difference between the two approaches for the assay of the drug in its dosage form. Furthermore, the developed method was successfully applied for the assay of IMG in biological fluids including spiked human plasma and urine. The sustainability of the developed method was evaluated using the Analytical Eco-Scale, AGSA, and ComplexMoGAPI, metrics. Owing to its simplicity, sensitivity, and sustainability, the proposed fluorimetric assay provides a green alternative for routine determination of IMG in pharmaceutical analysis.

本研究首次采用荧光法测定新型抗糖尿病药物依米霉素的含量。由于IMG缺乏天然荧光，我们利用一种新型生物启发亚麻籽衍生的碳量子点LIN-CQDs作为荧光探针来测定其荧光。在380 nm激发下，LIN-CQDs在470 nm处表现出较强的天然发射。利用透射电子显微镜（TEM）、能量色散x射线能谱（EDX）和x射线光电子能谱（XPS）对合成的LIN-CQDs进行了综合表征，证实了氮掺杂CQDs的成功形成。随着IMG浓度的增加，LIN-CQDs的荧光强度逐渐猝灭。对其淬火机理进行了研究，发现其遵循静态淬火过程。在0.15 ~ 3.0 μg/mL的浓度范围内，猝灭响应呈良好的线性关系。对影响淬火过程的实验条件进行了优化。该方法符合ICH指南，具有较高的准确性、精密度和特异性。与先前报道的高效液相色谱法进行统计比较的结果证实，两种方法对其剂型的测定没有明显差异。此外，所开发的方法已成功地应用于生物液体（包括加标的人血浆和尿液）中IMG的测定。采用分析生态尺度、AGSA和ComplexMoGAPI指标对所开发方法的可持续性进行了评估。由于其简单、敏感和可持续性，所提出的荧光测定法为药物分析中常规测定IMG提供了一种绿色替代方法。

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