[Changes in the blood system under chronic toxic exposure].

Abstract

On the basis of accumulated experience from the numerous investigations of the elements of the peripheral blood in workers of different areas in industry and agriculture a classification is made of the injuries of the blood system under chronic toxic effects. Results from the peripheral blood state of 200 workers with chronic exposure to benzol and other aromatic hydrocarbons are given, as well as for 155 agricultural workers in contact with pesticides for many years and 308 children of the region with polluted by heavy metals (mainly lead) environment. Attention is drawn, that both the acute intoxications and chronic toxic effects have provoking role for the manifestation of concealed congenital, not rarely genetically stimulated insufficiency of Gl-6-PHD, which is manifested clinically as haemolytic anemia and secretly proceeding hemoglobinopathies, which clinically develop as thalassemia at entering of toxic doses of drugs, heavy metals, pesticides in the organism.