Infusion of the GABAergic antagonist bicuculline into the medial septal area does not block the impairing effects of systemically administered midazolam on inhibitory avoidance retention

Heather Dickinson-Anson , James L. McGaugh
{"title":"Infusion of the GABAergic antagonist bicuculline into the medial septal area does not block the impairing effects of systemically administered midazolam on inhibitory avoidance retention","authors":"Heather Dickinson-Anson ,&nbsp;James L. McGaugh","doi":"10.1016/S0163-1047(05)80024-X","DOIUrl":null,"url":null,"abstract":"<div><p>This experiment investigated the effect of intraseptal administration of the GABAergic antagonist bicuculline methiodide on benzodiazepine-induced amnesia. Male Sprague-Dawley rats were implanted with cannula aimed at the medial septal area and allowed to recover for 1 week. Ten minutes prior to training in a continuous multiple trial inhibitory avoidance task, buffer solution or bicuculline methiodide (56 or 100 pmol/0.5 μl) was injected into the medial septal area. This infusion was immediately followed by systemic (ip) administration of saline or midazolam (1.5 or 3.0 mg/kg). In comparison with saline controls, animals given the higher dose of midazolam (3.0 mg/kg), required more trials to reach acquisition criterion (remaining in the starting chamber for 100 s). This midazolam-induced acquisition deficit was blocked by an intraseptal infusion of bicuculline methiodide (100 pmol). On a 48-h retention test the performance of animals given either dose of midazolam was significantly impaired relative to vehicle controls: Furthermore, although intraseptal infusion of bicuculline methiodide prior to systemic injection of midazolam blocked the midazolam-induced acquisition impairment, bicuculline did not block the midazolam-induced retention impairment. These results suggest that although the medial septal area may be involved in midazolam-induced acquisition deficits, this area is not a critical site of action for benzodiazepine-induced effects on inhibitory avoidance retention.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"62 3","pages":"Pages 253-258"},"PeriodicalIF":0.0000,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0163-1047(05)80024-X","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Behavioral and neural biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S016310470580024X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5

Abstract

This experiment investigated the effect of intraseptal administration of the GABAergic antagonist bicuculline methiodide on benzodiazepine-induced amnesia. Male Sprague-Dawley rats were implanted with cannula aimed at the medial septal area and allowed to recover for 1 week. Ten minutes prior to training in a continuous multiple trial inhibitory avoidance task, buffer solution or bicuculline methiodide (56 or 100 pmol/0.5 μl) was injected into the medial septal area. This infusion was immediately followed by systemic (ip) administration of saline or midazolam (1.5 or 3.0 mg/kg). In comparison with saline controls, animals given the higher dose of midazolam (3.0 mg/kg), required more trials to reach acquisition criterion (remaining in the starting chamber for 100 s). This midazolam-induced acquisition deficit was blocked by an intraseptal infusion of bicuculline methiodide (100 pmol). On a 48-h retention test the performance of animals given either dose of midazolam was significantly impaired relative to vehicle controls: Furthermore, although intraseptal infusion of bicuculline methiodide prior to systemic injection of midazolam blocked the midazolam-induced acquisition impairment, bicuculline did not block the midazolam-induced retention impairment. These results suggest that although the medial septal area may be involved in midazolam-induced acquisition deficits, this area is not a critical site of action for benzodiazepine-induced effects on inhibitory avoidance retention.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
将gaba能拮抗剂双库兰输注到内侧间隔区不能阻断全身给药咪达唑仑对抑制性回避保留的损害作用
本实验探讨了gaba能拮抗剂双库林对苯二氮卓类药物诱导的健忘症的影响。雄性Sprague-Dawley大鼠内间隔区插管,术后1周恢复。在连续多次试验抑制回避任务训练前10分钟,将缓冲液或双库兰(56或100 pmol/0.5 μl)注射到内侧间隔区。输注后立即全身(ip)给予生理盐水或咪达唑仑(1.5或3.0 mg/kg)。与生理盐水对照组相比,给予较高剂量的咪达唑仑(3.0 mg/kg)的动物需要更多的试验才能达到获得标准(在启动室中停留100秒)。这种咪达唑仑诱导的获得缺陷可以通过腹腔内输注双库兰(100 pmol)来阻断。在48小时的滞留试验中,给予任一剂量的咪达唑仑的动物的表现都明显低于对照组:此外,尽管在全身注射咪达唑仑之前,双库库林可阻断咪达唑仑诱导的习得障碍,但双库库林不能阻断咪达唑仑诱导的滞留障碍。这些结果表明,虽然内侧间隔区域可能参与了咪达唑仑诱导的习得缺陷,但该区域并不是苯二氮卓类药物诱导的抑制性回避保留效应的关键作用部位。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Mechanisms of alcohol abuse and alcoholism in adolescents: A case for developing animal models Hypobaric hypoxia impairs spatial memory in an elevation-dependent fashion Infusion of the GABAergic antagonist bicuculline into the medial septal area does not block the impairing effects of systemically administered midazolam on inhibitory avoidance retention Development and experience lead to increased volume of subcompartments of the honeybee mushroom body Place navigation in the morris water maze under minimum and redundant extra-maze cue conditions
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1