Facilitation of social learning by treatment with an NMDA receptor antagonist

Renate Lederer, Elisabeth Radeke, Cesare Mondadori
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引用次数: 18

Abstract

A single oral treatment with 0.3 mg/kg of the competitive NMDA receptor blocker CGP 37 849 improved the retention performance of rats in a social memory paradigm. The effect disappeared with increasing doses: at 1 mg/kg a positive trend could still be observed; at 3 mg/kg no effect whatever was detectable.

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NMDA受体拮抗剂对社会学习的促进作用
单次口服0.3 mg/kg竞争性NMDA受体阻滞剂CGP 37849可改善大鼠在社会记忆范式中的保留表现。该效应随着剂量的增加而消失:在1 mg/kg时仍可观察到阳性趋势;在3毫克/千克的浓度下,没有检测到任何影响。
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