Induction of a 60-kDa heat shock protein in rat pancreas by water-immersion stress.

M Otaka, H Itoh, T Kuwabara, A Zeniya, S Fujimori, Y Tashima, O Masamune
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Abstract

1. In this study, expression of a 60-kDa heat shock protein in rat pancreas was investigated before and after water-immersion stress, which has been known as an exacerbation factor of caerulein-induced pancreatitis in rats, by Western blot. 2. A 60-kDa heat shock protein increased after water-immersion stress in both soluble and insoluble fractions of the pancreas. 3. Serum amylase level and pancreas weight did not increase after water-immersion. 4. No pathologic alteration was observed in the pancreas after water-immersion.

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水浸应激诱导大鼠胰腺60 kda热休克蛋白的研究。
1. 本研究采用Western blot方法研究了一种60 kda的热休克蛋白在水浸应激前后在大鼠胰腺中的表达,该蛋白被认为是小蛋白诱导的大鼠胰腺炎的加重因子。2. 在胰腺的可溶性和不溶性部分中,60 kda的热休克蛋白在水浸应激后增加。3.水浸后血清淀粉酶水平和胰腺重量均未增加。4. 胰腺经水浸泡后未见病理改变。
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