Comparative examination of Adalat and Cordaflex in anti-ischaemic therapy.

Abstract

The efficacy of Cordaflex (EGIS) and Adalat (Bayer), both containing 10 mg nifedipine, has been examined in ischaemic cardiopathic patients. The fifteen ischaemic cardiopathic patients were treated with identical doses of Cordaflex and Adalat, simultaneously with unchanged nitrate and beta-blocker therapy. The patients received 30-80-mg identical nifedipine doses daily for 1 week each. In 13 patients change was observed neither in the weekly nitroglycerin consumption nor in the time or intensity of silent and active ischaemic periods registered with 24-hour ECG monitoring. Significant change was observed in one patient during Cordaflex administration, in another patient during Adalat therapy. However, these changes were attributed either to the progression of, or to the spontaneous improvement in the primary disease. Considering the effect influencing blood pressure and heart rate, and one side-effect, there was no difference between the two products. The anti-ischaemic effect of Cordaflex and Adalat was found to be identical.