Okuda Y., Ezure M., Tsukahara K., Sawada T., Mizutani M., Katori T., Bannai C., Yamashita K.
{"title":"Eicosapentaenoic Acid Enhances Intracellular Free Calcium in Cultured Human EndothelialCells","authors":"Okuda Y., Ezure M., Tsukahara K., Sawada T., Mizutani M., Katori T., Bannai C., Yamashita K.","doi":"10.1006/bmmb.1994.1021","DOIUrl":null,"url":null,"abstract":"<div><p>Eicosapentaenoic acid (EPA) caused elevations of intracellular free Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>) measured by fura-2 fluorescence in cultured human endothelial cells. The EPA induced increase in [Ca<sup>2+</sup>]<sub>i</sub> could still be observed when either cyclooxygenase or lipoxygenase inhibitors were added. These results suggest that EPA itself rather than its metabolites has direct effects on intracellular Ca<sup>2+</sup> mobilization, causing the elevation of [Ca<sup>2+</sup>]<sub>i</sub>.</p></div>","PeriodicalId":8752,"journal":{"name":"Biochemical medicine and metabolic biology","volume":"51 2","pages":"Pages 166-168"},"PeriodicalIF":0.0000,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/bmmb.1994.1021","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemical medicine and metabolic biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0885450584710218","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 12
Abstract
Eicosapentaenoic acid (EPA) caused elevations of intracellular free Ca2+ concentration ([Ca2+]i) measured by fura-2 fluorescence in cultured human endothelial cells. The EPA induced increase in [Ca2+]i could still be observed when either cyclooxygenase or lipoxygenase inhibitors were added. These results suggest that EPA itself rather than its metabolites has direct effects on intracellular Ca2+ mobilization, causing the elevation of [Ca2+]i.
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