Accelerating behavioral recovery after cortical lesions

R.W. Russell , M.L. Escobar , R.A. Booth , F. Bermúdez-Rattoni
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引用次数: 18

Abstract

We recently demonstrated that insular cortex (IC) fetal implants supplemented by nerve growth factor (NGF) can accelerate the recovery of behavioral deficits induced by IC brain lesions. In the present report we describe results on in vivo assays of acetylcholine (ACh) turnover in the IC of rats subjected to the same brain lesion and implant treatments used in that research and for which detailed behavioral data are available. The neurochemical assays were carried out immediately after completion of the behavioral measurements. The assays showed that implants or NGF with heterotopic tissue continued to be associated with elevated levels of ACh and with deficits in learning and memory at a time postlesion when both behavior and ACh turnover in vivo, after treatment with homotopic implants and NGF combined, were at nonlesioned control levels. The results support the concept that, in vivo, the cholinergic neurotransmitter system is intimately involved in recovery from IC lesion-induced deficits in behavior and show that a combination of homotopic implant and NGF may be used as a means of manipulating that system to accelerate the repair of such deficits. Mechanisms by which this combination produces its effects are considered and the possibility is suggested that other neurotrophic factors (NTF) may also be useful when other types of brain lesions are involved.

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加速皮层损伤后的行为恢复
我们最近的研究表明,补充神经生长因子(NGF)的岛叶皮质(IC)胎儿植入物可以加速由IC脑损伤引起的行为缺陷的恢复。在本报告中,我们描述了在研究中使用的相同脑损伤和植入治疗的大鼠IC中乙酰胆碱(ACh)转换的体内测定结果,并提供了详细的行为数据。神经化学分析在行为测量完成后立即进行。实验显示,同种异位植入物和NGF联合治疗后,体内的行为和乙酰胆碱转换均处于非病变对照水平,而在病变后一段时间内,异位组织植入物或NGF继续与乙酰胆碱水平升高以及学习和记忆障碍相关。研究结果支持这样的观点,即在体内,胆碱能神经递质系统与IC损伤引起的行为缺陷的恢复密切相关,并表明同位植入物和NGF的结合可以作为操纵该系统的一种手段来加速这种缺陷的修复。考虑了这种组合产生其作用的机制,并建议其他神经营养因子(NTF)在涉及其他类型脑病变时也可能有用。
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