Cellular and subcellular alterations of the thyroid gland in rats caused by lithium carbonate.

Bulletin de l'Association des anatomistes Pub Date : 1993-06-01

F C Valle, H Hayashi, J C Prates, L J Didio

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Abstract

Biochemical, hematologic, histometric, structural and ultrastructural changes were studied in the thyroid gland of rats, whom were administered Lithium carbonate. It was noted that (1) the Li carbonate had a cumulative effect on the serum; (2) T3 and T4 hormones in the blood decreased throughout the experiment; (3) the red blood cells, hemoglobin, hematocrit, platelets and leukocytes decreased gradually; (4) the diameter of the thyroid follicles, the size of the follicular cells and colloid droplets decreased, whereas the stroma was invaded by a greater number of collagen fibers and blood capillaries.

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碳酸锂引起的大鼠甲状腺细胞和亚细胞改变。

观察碳酸锂给药后大鼠甲状腺的生化、血液学、组织学、结构及超微结构变化。结果表明:(1)碳酸锂对血清有累积效应;(2)在整个实验过程中，血液中T3、T4激素下降;(3)红细胞、血红蛋白、红细胞压积、血小板、白细胞逐渐减少;(4)甲状腺滤泡直径、滤泡细胞和胶体液滴大小减小，基质被大量胶原纤维和毛细血管浸润。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bulletin de l'Association des anatomistes

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