[Regulating effect of the hematopoiesis-inducing microenvironment on hematopoietic processes as affected by cytostatic drugs].

Abstract

The study of bone marrow hemopoiesis, the count of hemopoietic precursor cells, bone marrow structural and functional organization, the level of humoral stimulators and secretion by hemopoiesis-inducing microenvironment (HIM) cells following a single injection of 5-fluorouracil, cyclophosphamide or adriamycin has found out that cytostatic-related changes in hemopoiesis recovery depend primarily on relationships between proliferation and differentiation of hemopoietic cells. These relationships are dictated by the state of HIM cells. Enhanced functional activity of HIM elements in response to hemopoietic tissue damage caused by adriamycin or cyclophosphamide promotes rapid hemopoiesis regeneration. At the same time, 5-fluorouracil gave rise to prolonged bone marrow hypoplasia, severe disorder of microenvironment cell function.