{"title":"Epidemiological, virological, and clinical features of an epidemic of hand, foot, and mouth disease in England and Wales.","authors":"J W Bendig, D M Fleming","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>We describe the epidemiological, virological, and clinical features of an epidemic of hand, foot, and mouth disease, attributed to coxsackie A virus serotype 16, that occurred throughout England and Wales in the last quarter of 1994. Nine hundred and fifty-two cases were reported by spotter practices that make weekly returns to the Royal College of General Practitioners, which made this the largest epidemic of hand, foot, and mouth disease in England and Wales reported to date. Most patients were aged 1 to 4 years and lived in central or southern regions. Clinical features were unavailable from the weekly returns but were described in detail for 39 patients, mostly by means of a questionnaire to general practitioners near the PHLS Coxsackie Reference Laboratory. All cases had a rash on their hands and 23 also had rashes on their feet and in their mouths. Most cases were mild. Severity was associated with the degree of mouth involvement. Secondary cases in family members were rare. Data from the Royal College of General Practitioners since 1963 reveal a period between epidemics of two to three years. The epidemics in 1988 and 1990 also occurred in the last quarters of these years and cases were concentrated in the central and southern regions.</p>","PeriodicalId":77078,"journal":{"name":"Communicable disease report. CDR review","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1996-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Communicable disease report. CDR review","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
We describe the epidemiological, virological, and clinical features of an epidemic of hand, foot, and mouth disease, attributed to coxsackie A virus serotype 16, that occurred throughout England and Wales in the last quarter of 1994. Nine hundred and fifty-two cases were reported by spotter practices that make weekly returns to the Royal College of General Practitioners, which made this the largest epidemic of hand, foot, and mouth disease in England and Wales reported to date. Most patients were aged 1 to 4 years and lived in central or southern regions. Clinical features were unavailable from the weekly returns but were described in detail for 39 patients, mostly by means of a questionnaire to general practitioners near the PHLS Coxsackie Reference Laboratory. All cases had a rash on their hands and 23 also had rashes on their feet and in their mouths. Most cases were mild. Severity was associated with the degree of mouth involvement. Secondary cases in family members were rare. Data from the Royal College of General Practitioners since 1963 reveal a period between epidemics of two to three years. The epidemics in 1988 and 1990 also occurred in the last quarters of these years and cases were concentrated in the central and southern regions.
我们描述了1994年第四季度发生在英格兰和威尔士的一次由柯萨奇A型16血清型病毒引起的手足口病流行病学、病毒学和临床特征。每周返回皇家全科医师学院的检举人报告了952例病例,这使得这成为迄今为止在英格兰和威尔士报告的最大的手足口病流行病。大多数患者年龄在1至4岁之间,居住在中部或南部地区。临床特征无法从每周报告中获得,但对39名患者进行了详细描述,主要是通过向PHLS柯萨奇参考实验室附近的全科医生进行问卷调查。所有患者的手上都有皮疹,23例患者的脚和嘴部也有皮疹。大多数病例病情轻微。严重程度与口腔受累程度有关。家族成员继发病例罕见。英国皇家全科医师学院(Royal College of General Practitioners)自1963年以来的数据显示,两次流行之间的间隔为两到三年。1988年和1990年的流行病也发生在这几年的最后几个季度,病例集中在中部和南部地区。