[Toxicity in rats fed diet containing iron lactate for 26 weeks].

K Takegawa, K Yasuhara, K Mitsumori, H Onodera, T Shimo, M Takahashi
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Abstract

In order to characterize the toxicity of iron lactate, a 26-week feeding study was performed in male and female F344 rats. Animals were divided into 2 groups, and given diet containing iron lactate at concentration of 0 or 2%. No animals died during the administration period. Body weight gain was suppressed in both sexes of the 2% group compared with the 0% group. Hematologically, anemia was observed in male of the 2% group. Serum alkaline phosphatase decreased in both sexes of the 2% group. The spleen weight of both sexes and kidney weight of females were higher in the 2% group than in the 0% group. Lipid peroxide increased not only in the liver and the kidney homogenates of treated males and females, but also in the serum of treated females. Histopathologically, iron deposition was observed in the liver, the kidney and the spleen of treated males and females, and in the intestine of treated females. The present results indicate that the iron lactate administration caused iron deposition in the liver and the other several organs, resulting in lipid peroxidation in these organs.

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[饲喂含乳酸铁饲料26周大鼠的毒性研究]。
为了研究乳酸铁的毒性,我们对F344大鼠进行了为期26周的饲养试验。试验动物分为2组,分别饲喂浓度为0或2%的乳酸铁饲料。管理期间无动物死亡。与0%组相比,2%组的男女体重增加都受到抑制。血液学上,2%组男性出现贫血。2%组男女血清碱性磷酸酶均下降。2%添加量组男女脾脏重量和雌性肾脏重量均高于0%添加量组。过氧化脂质不仅在雄性和雌性的肝脏和肾脏匀浆中增加,而且在雌性的血清中也增加。在组织病理学上,雄性和雌性的肝脏、肾脏和脾脏以及雌性的肠道都有铁沉积。目前的研究结果表明,乳酸铁引起肝脏和其他几个器官的铁沉积,导致这些器官的脂质过氧化。
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