{"title":"[The effect of erythropoietin on megakaryocytopoiesis depressed by dialysable substances in experimental animals].","authors":"R Zorcheva, D Nenov, E Diankov","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The aim of the study is to examine influence of r-Hu-Ero on megakaryocytopoiesis in rats with depressed by dialysable substances thrombocytopoiesis. Experimental animals are male Wistar rats, treated with bidestilled water, used dialysis solution and r-Hu-Ero. We investigate bone marrow of experimental rats. More expressed increase of megakaryocyte count \"pro mile\" in rats with depressed megakaryocytopoiesis, as well as influence on megakaryocyte maturation for shorter period of time, provide evidence to be accepted that megakaryocytopoiesis, depressed by dialysable substances is more sensitive to stimulating effect of r-Hu-Ero. The reason for this enhanced sensitivity at present appear unclear.</p>","PeriodicalId":11560,"journal":{"name":"Eksperimentalna meditsina i morfologiia","volume":"32 3-4","pages":"49-56"},"PeriodicalIF":0.0000,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eksperimentalna meditsina i morfologiia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The aim of the study is to examine influence of r-Hu-Ero on megakaryocytopoiesis in rats with depressed by dialysable substances thrombocytopoiesis. Experimental animals are male Wistar rats, treated with bidestilled water, used dialysis solution and r-Hu-Ero. We investigate bone marrow of experimental rats. More expressed increase of megakaryocyte count "pro mile" in rats with depressed megakaryocytopoiesis, as well as influence on megakaryocyte maturation for shorter period of time, provide evidence to be accepted that megakaryocytopoiesis, depressed by dialysable substances is more sensitive to stimulating effect of r-Hu-Ero. The reason for this enhanced sensitivity at present appear unclear.
本研究旨在探讨r- ho - ero对可透析物质血小板生成抑制大鼠巨核细胞生成的影响。实验动物为雄性Wistar大鼠，用沸水、透析液和r-Hu-Ero处理。我们研究了实验大鼠的骨髓。巨核细胞生成抑制大鼠巨核细胞计数“亲哩”增加较多，对巨核细胞成熟的影响时间较短，证明可透析物质抑制的巨核细胞生成对r-Hu-Ero的刺激作用更为敏感。目前还不清楚这种敏感性增强的原因。
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