Another function of erythrocytes: transport of circulating immune complexes.

Infusionstherapie und Transfusionsmedizin Pub Date : 1995-10-01 DOI:10.1159/000223148

M Pascual, J A Schifferli

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引用次数: 14

Abstract

Objective: To review the main characteristics of the 'immune complex (IC) transport system of erythrocytes', and its possible relevance for transfusion medicine.

Data sources: Literature search, and results Of Studies performed in the laboratory of Dr J. Schifferli from 1986 to 1995.

Selection criteria: Peer review journals and work relevant to the topic.

Results: When antigen/antibody IC form in the presence of complement. C3b binds covalently to the complexes. Such opsonized complexes attach to cells bearing complement receptor 1 (CR1), which is mostly found on erythrocytes in the circulation. This allows IC to be transported through the circulation to the fixed macrophage system of the liver and spleen. In addition, C3b bound to the complexes is catabolized by factor 1 (with CR1 as a cofactor) so that the complement-activating properties of the complexes are reduced.

Conclusions: Complement and erythrocyte CR1 contribute to the safe and effective elimination of IC in humans. This physiologic system prevents IC deposition in the vessel walls.

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红细胞的另一个功能:运输循环免疫复合物。

目的:综述“红细胞免疫复合物(IC)转运系统”的主要特征及其在输血医学中的可能意义。资料来源:文献检索和J. Schifferli博士实验室1986 - 1995年的研究结果。选择标准:同行评审的期刊和与主题相关的工作。结果:抗原/抗体在补体存在下形成IC。C3b与配合物共价结合。这种调理的复合物附着在携带补体受体1 (CR1)的细胞上，而补体受体1主要存在于循环中的红细胞上。这使得IC可以通过循环运输到肝脏和脾脏的固定巨噬细胞系统。此外，与复合物结合的C3b被因子1分解代谢(CR1作为辅助因子)，从而降低复合物的补体活化特性。结论:补体和红细胞CR1有助于人类安全有效地消除IC。这一生理系统可防止IC沉积在血管壁上。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Infusionstherapie und Transfusionsmedizin

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