Alpha2 adrenoceptor agonists in the horse—Areview

G.C.W. England, K.W. Clarke
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引用次数: 174

Abstract

In recent years the usefulness of the alpha,, adrenoceptor agonist drugs has been recognized in equine practice. Several agents have become available and are now licensed for use in a number of countries. The principle actions of all alpha2 adrenoceptor agonists are similar, in that they produce a reduction in heart rate and alteration of heart rhythm, an initial hypertension followed by a prolonged hypotension, a decrease in tile cardiac output and respiratory depression. For clinical purposes, these agents produce sedation and analgesia, they are useful for premedication and markedly potentiate the effects of other sedative/analgesic agents. Differences in receptor specificity between the alpha2 adrenoceptor agonists results in the distinguishing characteristics of the individual agents, particularly with respect to their duration of action, sedative effect and analgesic properties; their cardiopulmonary effects are however similar, when equipotent sedative closes are administered. When used in combination with other agents, the alpha2 adrenoceptor agonists all appear to act in a similar manner, with the greatest difference being related to their duration of action.

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α 2肾上腺素受体激动剂在马的视野
近年来,肾上腺素能受体激动剂药物的有效性已在马的实践中得到认可。目前已有几种药剂可供使用,并已在若干国家获得使用许可。所有的α 2肾上腺素能受体激动剂的主要作用是相似的,因为它们产生心率降低和心律改变,最初的高血压,随后是长时间的低血压,心输出量减少和呼吸抑制。对于临床目的,这些药物产生镇静和镇痛作用,它们可用于药物前治疗,并显著增强其他镇静/镇痛药物的作用。α 2肾上腺素能受体激动剂之间受体特异性的差异导致了个体药物的不同特征,特别是在作用时间、镇静作用和镇痛特性方面;然而,当给予同等效力的镇静剂时,它们的心肺作用是相似的。当与其他药物联合使用时,α 2肾上腺素能受体激动剂的作用方式似乎都相似,最大的差异与它们的作用时间有关。
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