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Abstracts of Literature 文学摘要
Pub Date : 2005-01-01 DOI: 10.1016/S0007-1935(17)47207-1
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引用次数: 0
Alpha2 adrenoceptor agonists in the horse—Areview α 2肾上腺素受体激动剂在马的视野
Pub Date : 1996-11-01 DOI: 10.1016/S0007-1935(96)80118-7
G.C.W. England, K.W. Clarke

In recent years the usefulness of the alpha,, adrenoceptor agonist drugs has been recognized in equine practice. Several agents have become available and are now licensed for use in a number of countries. The principle actions of all alpha2 adrenoceptor agonists are similar, in that they produce a reduction in heart rate and alteration of heart rhythm, an initial hypertension followed by a prolonged hypotension, a decrease in tile cardiac output and respiratory depression. For clinical purposes, these agents produce sedation and analgesia, they are useful for premedication and markedly potentiate the effects of other sedative/analgesic agents. Differences in receptor specificity between the alpha2 adrenoceptor agonists results in the distinguishing characteristics of the individual agents, particularly with respect to their duration of action, sedative effect and analgesic properties; their cardiopulmonary effects are however similar, when equipotent sedative closes are administered. When used in combination with other agents, the alpha2 adrenoceptor agonists all appear to act in a similar manner, with the greatest difference being related to their duration of action.

近年来,肾上腺素能受体激动剂药物的有效性已在马的实践中得到认可。目前已有几种药剂可供使用,并已在若干国家获得使用许可。所有的α 2肾上腺素能受体激动剂的主要作用是相似的,因为它们产生心率降低和心律改变,最初的高血压,随后是长时间的低血压,心输出量减少和呼吸抑制。对于临床目的,这些药物产生镇静和镇痛作用,它们可用于药物前治疗,并显著增强其他镇静/镇痛药物的作用。α 2肾上腺素能受体激动剂之间受体特异性的差异导致了个体药物的不同特征,特别是在作用时间、镇静作用和镇痛特性方面;然而,当给予同等效力的镇静剂时,它们的心肺作用是相似的。当与其他药物联合使用时,α 2肾上腺素能受体激动剂的作用方式似乎都相似,最大的差异与它们的作用时间有关。
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引用次数: 174
Pub Date : 1996-11-01 DOI: 10.1016/S0007-1935(96)80134-5
S.J.G. Hall
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引用次数: 0
Pub Date : 1996-11-01 DOI: 10.1016/S0007-1935(96)80143-6
J.D. Littlewood
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引用次数: 0
Managing a Veterinary Practice, D.C. Jack (Ed.). W. B. Saunders, London (1994), ISBN: 0-9205-1311-5 管理兽医实践,华盛顿杰克(编辑)。w.b. Saunders,伦敦(1994),ISBN: 0-9205-1311-5
Pub Date : 1996-11-01 DOI: 10.1016/S0007-1935(96)80126-6
D. Thompson
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引用次数: 0
Pub Date : 1996-11-01 DOI: 10.1016/S0007-1935(96)80147-3
G.R. Lamb
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引用次数: 0
Livestock Housing 牲畜住房
Pub Date : 1996-11-01 DOI: 10.1016/S0007-1935(96)80131-X
D.W.B. Sainsbury
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引用次数: 28
Evaluation of a nutritive oral rehydration solution for the treatment of calf diarrhoea 一种营养口服补液治疗小牛腹泻的评价
Pub Date : 1996-11-01 DOI: 10.1016/S0007-1935(96)80123-0
Harriet W. Brooks, D.G. White, A.J. Wagstaff, A.R. Michell

The essential constituents of a conventional oral rehydration solution (ORS) are sodium, glucose and a bicarbonate precursor. The glucose promotes sodium uptake but because these solutions are isotonic, it is insufficient to sustain calorie requirements. This paper examines the performance of a novel ORS with over three times the conventional glucose concentration, by comparing it with two leading commercial ORSs in calves with induced Escherichia coli diarrhoea. This solution showed greater ability than the current market-leading ORS to repair extracellular fluid and plasma volume and to correct both hyponatraemia and metabolic acidosis, especially in more severely affected calves. In acidotic calves it was more effective in correcting hyperkalaemia, probably by supplying glucose to promote cellular potassium uptake as well as by correcting the acidosis. It therefore appears possible to depart from the traditional isotonic formulations for calf ORSs and gain significant nutritional support while retaining effective rehydration and correction of acid-base and electrolyte disturbances. This seems especially important in young animals where energy deprivation imposes a particular penalty; the use of hypertonic ORSs should not, however, be extended to other species without further research.

传统口服补液(ORS)的基本成分是钠、葡萄糖和碳酸氢盐前体。葡萄糖促进钠的吸收,但由于这些溶液是等渗的,它不足以维持卡路里的需求。本文研究了一种新型口服补液的性能超过三倍的常规葡萄糖浓度,通过比较它与两种领先的商业口服补液犊牛诱导大肠杆菌腹泻。与目前市场领先的ORS相比,该溶液在修复细胞外液和血浆容量以及纠正低钠血症和代谢性酸中毒方面表现出更强的能力,特别是在受影响更严重的小牛中。在酸性小牛中,它对纠正高钾血症更有效,可能是通过提供葡萄糖来促进细胞钾的摄取以及纠正酸中毒。因此,似乎有可能脱离传统的小牛ORSs等渗配方,获得显著的营养支持,同时保持有效的补液和纠正酸碱和电解质紊乱。这对幼小的动物来说似乎尤其重要,因为能量剥夺会给它们带来特殊的惩罚;然而,在没有进一步研究的情况下,不应将高渗ORSs的使用扩展到其他物种。
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引用次数: 25
Prospects for subunit vaccines against tick borne diseases 蜱传疾病亚单位疫苗的发展前景
Pub Date : 1996-11-01 DOI: 10.1016/S0007-1935(96)80117-5
A.J. Musoke , G.H. Palmer , T.F. McElwain , V. Nene , D. McKeever

Tick-borne parasites are a serious impediment to the improvement of livestockproduction in the developing world. The major parasites affecting cattle include Theileria parva, T. annulata, Babesia bigemina, B. bovis, Anaplasma marginale and Cowdria ruminantium. The control of these infections is dependent on the use of acaricides to decrease transmission by the tick vectors, and immunization of susceptible animals with live vaccines. The use of acaricide is hampered by the development of resistance, and live vaccines require cold chain facilities, which are generally unreliable in developing countries. There is therefore a need for improved vaccines that can circumvent these problems. There is a subunit vaccine being developed for T. parva based on the major surface antigen of the sporozoite (p67). A similar antigen, SPAG 1, has been identified as a candidate for T. annulata. Although several candidate antigens have been identified for Babesia spp., progress towards development of a subunit vaccine based on these antigens has been hampered by polymorphism among isolates and between species, and lack of knowledge of the immune effector mechanisms responsible for protection. The search for protective antigens of A. marginale has focused on outer membrane proteins; immunization with a variety of these antigens alone or in combination, has yielded promising results. As with Babesia, further definition of immune effector mechanisms is needed to optimize immunization strategies. The work on identifying the protective antigens of C. ruminantium is in its embryonic stages; however, two antigens have been identified and are currently being evaluated. There is high expectancy for subunit vaccines for all these diseases; however there is need for further work to elucidate the immune mechanisms in order to select appropriate antigen delivery systems.

蜱传寄生虫是发展中国家改善畜牧业生产的一个严重障碍。影响牛的主要寄生虫包括细小梭菌、环虫、双生巴贝斯虫、牛b虫、边缘无原体和反刍牛瘟虫。这些感染的控制取决于使用杀螨剂以减少蜱虫媒介的传播,以及使用活疫苗对易感动物进行免疫接种。杀螨剂的使用受到耐药性发展的阻碍,而活疫苗需要冷链设施,这在发展中国家通常是不可靠的。因此,有必要改进疫苗,以避免这些问题。基于孢子子的主要表面抗原,目前正在研制一种针对细小绦虫的亚单位疫苗(p67)。一个类似的抗原,SPAG 1,已被确定为环状虫的候选抗原。虽然已经确定了巴贝斯虫的几种候选抗原,但由于分离株之间和物种之间的多态性以及缺乏对负责保护的免疫效应机制的了解,基于这些抗原的亚单位疫苗的开发进展受到阻碍。对边缘芽孢杆菌保护性抗原的研究主要集中在外膜蛋白上;单独或联合使用多种抗原进行免疫接种已产生了令人鼓舞的结果。与巴贝斯虫一样,需要进一步确定免疫效应机制以优化免疫策略。瘤胃C. ruminantium保护性抗原的鉴定工作尚处于萌芽阶段;然而,已经确定了两种抗原,目前正在进行评估。对所有这些疾病的亚单位疫苗的期望很高;然而,为了选择合适的抗原递送系统,还需要进一步的工作来阐明免疫机制。
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引用次数: 23
Sex Determination, Differentiation and Intersexuality in Placental Mammals 胎盘哺乳动物的性别决定、分化和间性
Pub Date : 1996-11-01 DOI: 10.1016/S0007-1935(96)80141-2
A.P.F. Flint
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引用次数: 2
期刊
British Veterinary Journal
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