{"title":"Y Chromosome (Yq11) Microdeletions in Idiopathic Azoospermia","authors":"Toshiro Shirakawa, Masato Fujisawa, Masanori Kanzaki, Hiroshi Okada, Soichi Arakawa, Sadao Kamidono","doi":"10.1111/j.1442-2042.1997.tb00170.x","DOIUrl":null,"url":null,"abstract":"<p> <b>Background</b> Cytogenetic anomalies and molecular deletions of the Y chromosome in idiopathically sterile men suggest that genetic factor(s) controlling spermatogenesis are located in the distal portion of Yq11. We studied Y chromosome microdeletions in the Yq11.23 region in idiopathic azoospermia.</p><p> <b>Methods</b> We studied 25 azoospermic male patients with a cytogenetically normal 46XY karyotype; 1 3 exhibited Sertoli-cell-only syndrome and 12 exhibited maturation arrest. Microdeletions in the Yql 1 region were examined using the PCR technique with 4 pairs of primers from DNA loci in Yq11.23.</p><p> <b>Results</b> Microdeletions in Yq11.23 were detected in 4 of the 25 azoospermic men. The most common deletion was of the Y6HP52pr sequence, which was detected in 3 of 13 men with Sertoli-cell-only syndrome but in only 1 of 12 with maturation arrest.</p><p> <b>Conclusion</b> Detection of microdeletions within the Yq11 sequence is an important clue to the genetic factor(s) underlying azoospermia.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"4 2","pages":"198-201"},"PeriodicalIF":1.8000,"publicationDate":"2007-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1442-2042.1997.tb00170.x","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Urology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/j.1442-2042.1997.tb00170.x","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 6
Abstract
Background Cytogenetic anomalies and molecular deletions of the Y chromosome in idiopathically sterile men suggest that genetic factor(s) controlling spermatogenesis are located in the distal portion of Yq11. We studied Y chromosome microdeletions in the Yq11.23 region in idiopathic azoospermia.
Methods We studied 25 azoospermic male patients with a cytogenetically normal 46XY karyotype; 1 3 exhibited Sertoli-cell-only syndrome and 12 exhibited maturation arrest. Microdeletions in the Yql 1 region were examined using the PCR technique with 4 pairs of primers from DNA loci in Yq11.23.
Results Microdeletions in Yq11.23 were detected in 4 of the 25 azoospermic men. The most common deletion was of the Y6HP52pr sequence, which was detected in 3 of 13 men with Sertoli-cell-only syndrome but in only 1 of 12 with maturation arrest.
Conclusion Detection of microdeletions within the Yq11 sequence is an important clue to the genetic factor(s) underlying azoospermia.
期刊介绍：
International Journal of Urology is the official English language journal of the Japanese Urological Association, publishing articles of scientific excellence in urology. Submissions of papers from all countries are considered for publication. All manuscripts are subject to peer review and are judged on the basis of their contribution of original data and ideas or interpretation.
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