Regulation of the LDL receptor gene expression by hormones.

R Streicher, J Kotzka, D Müller-Wieland, W Krone
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Abstract

Promoter activity of the LDL receptor gene is stimulated by insulin and estradiol and mediated by SRE-1, which acts as a hormone sensitive cis-elemente. Using the antisense technique we reveal that SREBP-1 is selectively involved in the signal transduction pathway of insulin and IGF-I.

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激素对LDL受体基因表达的调控。
低密度脂蛋白受体基因的启动子活性由胰岛素和雌二醇刺激,并由SRE-1介导,SRE-1作为激素敏感的顺式元件。利用反义技术,我们发现SREBP-1选择性参与胰岛素和IGF-I的信号转导途径。
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