[Kinetics of conformational changes of methemoglobin complexed with liposomes].

G P Gorbenko
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Abstract

Kinetics of methemoglobin structural changes in the complex with liposomes composed of phosphatidylcholine and its mixtures with cardiolipin has been studied. The amplitudes and rate constants of the two observed kinetic phases are determined. The fast kinetic phase is attributed to the formation of the unstable intermediate protein form, while the slow one is assumed to reflect dissociation of the heme--globin complex.

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[高铁血红蛋白与脂质体复合物构象变化动力学]。
研究了高铁血红蛋白与磷脂酰胆碱组成的脂质体及其与心磷脂的混合物在复合物中的结构变化动力学。确定了两个观察到的动力学相的振幅和速率常数。快速的动力学阶段归因于不稳定的中间蛋白形式的形成,而缓慢的动力学阶段被认为反映了血红素-球蛋白复合物的解离。
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