{"title":"Effect of valproic acid on the pharmacokinetic profile of oxcarbazepine in the rat","authors":"K.M Matar , P.J Nicholls , S.A Bawazir , M.I Al-Hassan , A Tekle","doi":"10.1016/S0031-6865(98)00030-2","DOIUrl":null,"url":null,"abstract":"<div><p><span>The pharmacokinetics<span> of oxcarbazepine (30 mg kg</span></span><sup>−1</sup><span>, po), administered for 1 week, was studied in rats pre-treated for 2 weeks with valproic acid (100 mg kg</span><sup>−1</sup><span>, po). Oxcarbazepine (OXC) plasma levels were measured over a period of 24 h from dosing, using a sensitive HPLC method. No significant changes were observed in the mean values of OXC pharmacokinetic parameters (</span><em>C</em><sub>max</sub>, <em>T</em><sub>max</sub>, <em>t</em><sub>1/2</sub> and AUC<sub>o–oo</sub>) between the control and the pre-treated groups. The findings of this study suggest that OXC metabolism in the rat is apparently not affected by valproic acid, and the lack of effect may be attributed to the different pathways of biotransformation of the two drugs.</p></div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"73 5","pages":"Pages 247-250"},"PeriodicalIF":0.0000,"publicationDate":"1999-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(98)00030-2","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutica acta Helvetiae","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031686598000302","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
The pharmacokinetics of oxcarbazepine (30 mg kg−1, po), administered for 1 week, was studied in rats pre-treated for 2 weeks with valproic acid (100 mg kg−1, po). Oxcarbazepine (OXC) plasma levels were measured over a period of 24 h from dosing, using a sensitive HPLC method. No significant changes were observed in the mean values of OXC pharmacokinetic parameters (Cmax, Tmax, t1/2 and AUCo–oo) between the control and the pre-treated groups. The findings of this study suggest that OXC metabolism in the rat is apparently not affected by valproic acid, and the lack of effect may be attributed to the different pathways of biotransformation of the two drugs.
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