Spectrophotometric determination of aluminium in pharmaceutical preparations by azo dyes of 1,2,4-triazole series

Stanisław Zaręba , Jerzy Melke
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引用次数: 15

Abstract

Azodyes, derivatives of 1,2,4-triazole and pyrocatechine: 3-(3′,4′-dihydroxyphenylazo-1′)-1,2,4-triazole (TRIAP) and 3-(3′,4′-dihydroxyphenylazo-1′)-5-mercapto-1,2,4-triazole (METRIAP), were used for spectrophotometric determination of Al. in composite pharmaceutical preparations. In aqueous-methanolic solution at pH 6.20–6.50 Al ions form stabile, orange chelates. Molar ratio L:Al. is 2:1 (TRIAP) or 3:1 (METRIAP) and stability constants, expressed by log K, are 12,604 (METRIAP) and 8,440 (TRIAP). Other components of these preparations, particularly Mg, do not disturb Al determination. The determination results were statistically calculated and compared with those obtained by the method of atomic absorption spectrophotometry (AAS). The advantage of the developed method is easy synthesis of reagents, simple analytical procedure, stability of formed complexes, good reproducibility and accuracy of results. Using TRIAP or METRIAP the elaborated spectrophotometric method is more accurate than AAS method, for defined purpose.

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1,2,4-三唑系列偶氮染料分光光度法测定药物制剂中的铝
采用1,2,4-三唑和邻儿茶素的偶氮衍生物:3-(3 ',4 ' -二羟基苯基偶氮-1 ')-1,2,4-三唑(TRIAP)和3-(3 ',4 ' -二羟基苯基偶氮-1 ')-5-巯基-1,2,4-三唑(METRIAP)分光光度法测定复合药物制剂中al的含量。在pH值为6.20-6.50的甲醇水溶液中,Al离子形成稳定的橙色螯合剂。摩尔比L:Al。为2:1 (TRIAP)或3:1 (METRIAP),稳定常数用log K表示为12,604 (METRIAP)和8,440 (TRIAP)。这些制剂的其他成分,特别是镁,不会干扰铝的测定。对测定结果进行统计计算,并与原子吸收分光光度法(AAS)测定结果进行比较。该方法的优点是试剂合成容易,分析步骤简单,形成的配合物稳定,结果重现性和准确性好。使用TRIAP或METRIAP,详细的分光光度法比原子吸收法更准确,用于确定的目的。
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