HLA-A, -B, -C, -DRB1, DRB3, DRB4, DRB5 and DQB1 polymorphism detected by PCR-SSP in a semi-urban HIV-positive Ugandan population.

P Krausa, S McAdam, M Bunce, J Whitworth, B Biryahwaho, N French, B Tugume, C Gilks, F Gotch
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引用次数: 9

Abstract

PCR-SSP was used to HLA-type a cohort of Ugandan HIV-positive individuals. The results represent a more comprehensive description of HLA in an African population than previously described and are in concordance with data from a general Black population. Substantial differences exist between this population and Caucasoid populations in which immunological responses to HIV have been investigated; this emphasises that the main HLA-restrictive elements for HIV-specific cytotoxic T lymphocytes will most likely be different for each population.

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PCR-SSP检测乌干达半城市hiv阳性人群HLA-A, -B, -C, -DRB1, DRB3, DRB4, DRB5和DQB1多态性
采用PCR-SSP对乌干达hiv阳性个体进行hla分型。该结果代表了非洲人群HLA比以前描述的更全面的描述,并且与一般黑人人群的数据一致。该人群与高加索人群之间存在实质性差异,高加索人群对艾滋病毒的免疫反应已被调查;这强调了hiv特异性细胞毒性T淋巴细胞的主要hla限制性因素很可能在每个人群中是不同的。
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