Alterations in free radical scavenger system profile of type I diabetic rat brain.

Molecular and chemical neuropathology Pub Date : 1998-08-01 DOI:10.1007/BF02815124

S K Bhardwaj, P Sharma, G Kaur

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引用次数: 18

Abstract

The activities of the enzymes related to glutathione synthesis, degradation, and functions as well as reactive oxygen scavenging enzymes were analyzed in different brain regions, such as cerebral hemisphere, cerebellum, brainstem, thalamus, and hypothalamus after 1 and 3 mo of streptozotocin-induced diabetes in rats. Parallel studies were also made in age-matched control rats and insulin-treated diabetic rats. The content of glutathione (GSH) and its synthesizing enzyme gamma-glutamylcystein synthetase and also superoxide dismutase (SOD) and catalase activities (reactive oxygen scavenging enzymes) were significantly decreased from almost all the brain regions studied. However, glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), gamma-glutamyl transpeptidase (gamma-GTP), and glutamine synthetase (GS) activities were increased in the diabetic rat brain. Insulin treatment to the diabetic rats resulted in partial to full recovery in these enzymes activities. The present results emphasize the potentially serious alterations of brain free radical scavenger system in uncontrolled Type I diabetes.

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1型糖尿病大鼠脑自由基清除系统的改变。

研究了链脲霉素诱导的糖尿病大鼠1、3个月后，大脑半球、小脑、脑干、丘脑、下丘脑等不同脑区谷胱甘肽合成、降解及功能相关酶的活性及活性氧清除酶的变化。在年龄匹配的对照大鼠和胰岛素治疗的糖尿病大鼠中也进行了平行研究。在几乎所有研究区域，谷胱甘肽(GSH)及其合成酶γ -谷氨酰半胱氨酸合成酶的含量、超氧化物歧化酶(SOD)和过氧化氢酶(活性氧清除酶)的活性均显著降低。然而，糖尿病大鼠脑内谷胱甘肽过氧化物酶(GPx)、谷胱甘肽还原酶(GR)、谷胱甘肽s -转移酶(GST)、γ -谷氨酰转肽酶(γ - gtp)和谷氨酰胺合成酶(GS)活性升高。胰岛素治疗可使糖尿病大鼠的这些酶活性部分或完全恢复。目前的研究结果强调了未控制的1型糖尿病患者脑自由基清除系统的潜在严重改变。

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Molecular and chemical neuropathology

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