[Age features of oxidative processes in rat liver caused by toxic damage from tetrachloromethane].

Abstract

It has been studied the effect of tetrachlormethane on the activity of the processes of microsomal mitochondrial and free radical oxidation in 3.8-10 and 20-24 month rats. The age peculiarities of the investigated processes have been ascertained. The introduction of CCl4 caused: the most increase of the level of free radical oxidation products in young animals. The activity of oxidative processes in microsomes were minimum in this group of animals. In old rats the contents of intermediate products of FRO increased in the least degree and end products--the same as young animals. The oxidative processes in mitochondria were decreased in the most degree in old rats. It has been concluded that the activation of free radical reactions by active metabolites of CCl4 plays the main role in progress of pathological processes in young animals and the covalent connection of low active radicals with proteins of membranes and enzymes in old rats.