Neuroendocrine (ECL cell) differentiation of spontaneous gastric carcinomas of cotton rats (Sigmodon hispidus).

Laboratory animal science Pub Date : 1999-06-01

H L Waldum, H Rørvik, S Falkmer, S Kawase

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Abstract

Background and purpose: Female inbred cotton rats develop adenocarcinomas in the oxyntic mucosa. Since a female preponderance is typical for enterochromaffin-like (ECL) cell tumors, we examined such tumors for ECL cells. Gastrin plays a decisive role in ECL cell tumorigenesis, so blood gastrin concentration and gastric mucosal pH were measured.

Methods: The stomachs from six female cotton rats (6 to 8 months old) were studied histologically, and at euthanasia, gastric mucosal pH was determined. Euthanasia was performed on 15 other female cotton rats of similar age for determination of blood gastrin values by radioimmunoassay (RIA) and gastric mucosal pH. Rats were classified macroscopically to have normal or thick oxyntic mucosa, with or without tumor.

Results: Among the six cotton rats studied histologically, two 6-month-old rats had normal and two others had thick gastric mucosa, whereas two 8-month-old rats had thick mucosa with tumors. The ECL cells were markedly hyperplastic in all rats with thick mucosa, and ECL cells were found in the neoplastic parenchyma. All cotton rats with normal-appearing gastric mucosa had pH <2.5, whereas 14 rats with thick mucosa had pH >3.1 and hypergastrinemia.

Conclusions: Gastrin may play a major role in ECL cell hyperplasia and, perhaps, in adenocarcinoma genesis.

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棉花大鼠自发性胃癌的神经内分泌(ECL)分化。

背景与目的:雌性近交系棉大鼠在氧合黏膜发生腺癌。由于肠嗜铬蛋白样(ECL)细胞肿瘤以女性为主，我们检查了这种肿瘤的ECL细胞。胃泌素在ECL细胞发生过程中起决定性作用，因此测定血胃泌素浓度和胃黏膜pH值。方法:对6 ~ 8月龄雌性棉花大鼠的胃进行组织学研究，并在安乐死时测定胃黏膜pH值。另取15只年龄相近的雌性棉花大鼠安乐死，用放射免疫法测定血胃泌素(RIA)和胃黏膜ph值。宏观上将大鼠分为正常或厚的氧合粘膜，有无肿瘤。结果:6月龄大鼠2只胃黏膜正常，2只胃黏膜增厚，8月龄大鼠2只胃黏膜增厚伴肿瘤。粘膜厚的大鼠均可见ECL细胞明显增生，肿瘤实质中可见ECL细胞。胃黏膜正常的棉花大鼠pH值均为3.1，胃泌素高。结论:胃泌素可能在ECL细胞增生和腺癌发生中起主要作用。

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Laboratory animal science

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